Caesar J, Jordan M, Hills M
Department of Medicine, Timaru General Hospital, Timaru, 7910, New Zealand.
Respir Med Case Rep. 2016 Nov 5;20:16-18. doi: 10.1016/j.rmcr.2016.11.002. eCollection 2017.
Eosinophilic cholecystitis (EC) is a rare inflammatory condition of the gallbladder, confirmed by a cellular infiltrate comprised of more than 90% eosinophils in the gallbladder wall on histological examination. Although the etiology of EC is largely unknown, local autoimmune reactions within the gallbladder wall to inflammatory mediators from distal sites of inflammation have been hypothesized. Talc pleurodesis (TP) is a common clinical procedure used within respiratory medicine. However, it is associated with activation of systemic acute inflammatory responses including an increase in serum interleukin-8 (IL-8), which is a potent mediator of eosinophil chemotaxis. We report a case of EC following a TP procedure for persistent, secondary pneumothorax.
嗜酸性粒细胞性胆囊炎（EC）是一种罕见的胆囊炎症性疾病，组织学检查显示胆囊壁有超过90%的嗜酸性粒细胞组成的细胞浸润可确诊。尽管EC的病因大多不明，但有人推测胆囊壁内针对来自远处炎症部位的炎症介质发生了局部自身免疫反应。滑石粉胸膜固定术（TP）是呼吸医学中常用的临床操作。然而，它与全身急性炎症反应的激活有关，包括血清白细胞介素-8（IL-8）升高，IL-8是嗜酸性粒细胞趋化的有效介质。我们报告一例因持续性继发性气胸行TP术后发生EC的病例。
