Pollard Thomas D
Department of Molecular Cellular and Developmental Biology, Yale University, 208103, New Haven, CT, 06520-8103, USA.
Department of Molecular Biophysics and Biochemistry, Yale University, 208103, New Haven, CT, 06520-8103, USA.
Handb Exp Pharmacol. 2017;235:331-347. doi: 10.1007/164_2016_44.
Seven decades of research have revealed much about actin structure, assembly, regulatory proteins, and cellular functions. However, some key information is still missing, so we do not understand the mechanisms of most processes that depend on actin. This chapter summarizes our current knowledge and explains some examples of work that will be required to fill these gaps and arrive at a mechanistic understanding of actin biology.
七十年的研究已揭示了许多关于肌动蛋白结构、组装、调节蛋白及细胞功能的信息。然而，一些关键信息仍缺失，因此我们尚不了解大多数依赖肌动蛋白的过程的机制。本章总结了我们目前的知识，并解释了一些为填补这些空白并实现对肌动蛋白生物学的机制性理解所需开展的研究工作示例。
