Bonnefoy J Y, Denoroy M C, Guillot O, Martens C L, Banchereau J
UNICET, Laboratory for Immunological Research, Dardilly, France.
J Immunol. 1989 Aug 1;143(3):864-9.
We studied whether normal human B cells would express IL-1 activity and transcribe IL-1 genes before or after activation through their Ag receptor. Anti IgM antibody-activated B cells expressed IL-1 alpha on the cell surface and secreted IL-1 beta. Optimal induction of IL-1 occurred within 16 h of anti-IgM activation. mRNA specific for both IL-1 alpha and IL-1 beta was also induced upon activation. It is likely that the expression of m-IL-1 alpha on activated B cells together with the secretion of IL-1 beta represent important contributions in the efficient Ag-presenting capacity of B cells to T cells.
我们研究了正常人B细胞在通过其抗原受体激活之前或之后是否会表达白细胞介素-1（IL-1）活性并转录IL-1基因。抗IgM抗体激活的B细胞在细胞表面表达IL-1α并分泌IL-1β。抗IgM激活后16小时内发生IL-1的最佳诱导。激活后也诱导了IL-1α和IL-1β特异的信使核糖核酸（mRNA）。活化B细胞上m-IL-1α的表达以及IL-1β的分泌可能对B细胞向T细胞有效呈递抗原的能力有重要贡献。
