State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
National Institutes for Food and Drug Control, Tiantan Xili 2, Beijing, 100050, China.
Sci Rep. 2016 Nov 22;6:37668. doi: 10.1038/srep37668.
Natural Cordyceps collected in Bhutan has been widely used as natural Cordyceps sinensis, an official species of Cordyceps used as Chinese medicines, around the world in recent years. However, whether Cordyceps from Bhutan could be really used as natural C. sinensis remains unknown. Therefore, DNA sequence, bioactive components including nucleosides and polysaccharides in twelve batches of Cordyceps from Bhutan were firstly investigated, and compared with natural C. sinensis. Results showed that the fungus of Cordyceps from Bhutan was C. sinensis and the host insect belonged to Hepialidae sp. In addition, nucleosides and their bases such as guanine, guanosine, hypoxanthine, uridine, inosine, thymidine, adenine, and adenosine, as well as compositional monosaccharides, partial acid or enzymatic hydrolysates, molecular weights and contents of polysaccharides in Cordyceps from Bhutan were all similar to those of natural C. sinensis. All data suggest that Cordyceps from Bhutan is a rational alternative of natural C. sinensis, which is beneficial for the improvement of their performance in health and medicinal food areas.
近年来，在全球范围内，从不丹采集的天然冬虫夏草被广泛用作中国传统药物中官方认可的冬虫夏草种类。然而，从不丹采集的冬虫夏草是否真的可以被用作天然冬虫夏草仍不得而知。因此，我们首次对来自不丹的 12 批冬虫夏草的 DNA 序列、核苷和多糖等生物活性成分进行了研究，并与天然冬虫夏草进行了比较。结果表明，不丹的冬虫夏草真菌是冬虫夏草，其宿主昆虫属于蝙蝠蛾科。此外，核苷及其碱基（如鸟嘌呤、鸟苷、次黄嘌呤、尿嘧啶、肌苷、胸苷、腺嘌呤和腺苷）以及组成单糖、部分酸或酶解产物、多糖的分子量和含量，都与天然冬虫夏草相似。所有数据表明，不丹的冬虫夏草是天然冬虫夏草的合理替代品，这有利于提高它们在保健品和药品领域的性能。
