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小GTP酶RhoB在生理与疾病中的作用

The RhoB small GTPase in physiology and disease.

作者信息

Vega Francisco M, Ridley Anne J

机构信息

a Instituto de Biomedicina de Sevilla, IBiS (Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) , Sevilla , Spain.

b Department of Medical Physiology and Biophysics , Universidad de Sevilla , Sevilla , Spain.

出版信息

Small GTPases. 2018 Sep 3;9(5):384-393. doi: 10.1080/21541248.2016.1253528. Epub 2016 Nov 22.

DOI:10.1080/21541248.2016.1253528
PMID:27875099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5997158/
Abstract

RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.

摘要

RhoB是一种Rho家族GTP酶，与RhoA和RhoC高度相似，但在细胞中具有不同的功能。其独特的C末端区域会发生特定的翻译后修饰，赋予RhoB不同的定位和功能。除了与RhoA和RhoC在肌动蛋白组织和细胞迁移中的共同作用外，RhoB还参与多种其他细胞过程，包括膜运输、细胞增殖、DNA修复和细胞凋亡。RhoB在小鼠中不是必需基因，但它参与了多种生理和病理过程。本文将讨论其多种作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f3/5997158/0d9d96111336/ksgt-09-05-1253528-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f3/5997158/d5a302ddd93f/ksgt-09-05-1253528-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f3/5997158/ea1d49531c0b/ksgt-09-05-1253528-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f3/5997158/97c69b91409c/ksgt-09-05-1253528-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f3/5997158/0d9d96111336/ksgt-09-05-1253528-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f3/5997158/d5a302ddd93f/ksgt-09-05-1253528-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f3/5997158/ea1d49531c0b/ksgt-09-05-1253528-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f3/5997158/97c69b91409c/ksgt-09-05-1253528-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f3/5997158/0d9d96111336/ksgt-09-05-1253528-g004.jpg

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