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Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage.

作者信息

Thastrup O, Dawson A P, Scharff O, Foder B, Cullen P J, Drøbak B K, Bjerrum P J, Christensen S B, Hanley M R

机构信息

Department of Clinical Chemistry, University Hospital, Copenhagen, Denmark.

出版信息

Agents Actions. 1989 Apr;27(1-2):17-23. doi: 10.1007/BF02222186.

DOI:10.1007/BF02222186
PMID:2787587
Abstract
摘要

相似文献

1
Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage.毒胡萝卜素,一种用于研究细胞内钙释放和储存的新型分子探针。
Agents Actions. 1989 Apr;27(1-2):17-23. doi: 10.1007/BF02222186.
2
A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells.一种新型肿瘤促进剂毒胡萝卜素,可在NG115 - 401L神经细胞中短暂增加细胞质游离钙离子浓度,而不产生肌醇磷酸。
Biochem J. 1988 Jul 1;253(1):81-6. doi: 10.1042/bj2530081.
3
Calcium homeostasis in Trypanosoma cruzi amastigotes: presence of inositol phosphates and lack of an inositol 1,4,5-trisphosphate-sensitive calcium pool.克氏锥虫无鞭毛体中的钙稳态:肌醇磷酸的存在及对肌醇-1,4,5-三磷酸敏感的钙池的缺失
Mol Biochem Parasitol. 1992 Jun;52(2):251-61. doi: 10.1016/0166-6851(92)90057-q.
4
Anti-Ig induces release of inositol 1,4,5-trisphosphate, which mediates mobilization of intracellular Ca++ stores in B lymphocytes.抗免疫球蛋白诱导肌醇1,4,5-三磷酸的释放,该物质介导B淋巴细胞内钙离子储存的动员。
J Immunol. 1986 Jul 15;137(2):708-14.
5
Vectorial Ca2+ flux from the extracellular space to the endoplasmic reticulum via a restricted cytoplasmic compartment regulates inositol 1,4,5-trisphosphate-stimulated Ca2+ release from internal stores in vascular endothelial cells.通过一个受限的细胞质区室,钙离子从细胞外空间向内质网的矢量通量调节血管内皮细胞中肌醇1,4,5-三磷酸刺激的细胞内钙库钙离子释放。
Biochem J. 1993 Oct 15;295 ( Pt 2)(Pt 2):357-66. doi: 10.1042/bj2950357.
6
Inositol trisphosphate and thapsigargin discriminate endoplasmic reticulum stores of calcium in rat brain.肌醇三磷酸和毒胡萝卜素可区分大鼠脑中内质网的钙储备。
Biochem Biophys Res Commun. 1990 Oct 30;172(2):811-6. doi: 10.1016/0006-291x(90)90747-b.
7
Inositol 1,4,5-trisphosphate and 5'-GTP induce calcium release from different intracellular pools.肌醇1,4,5-三磷酸和5'-鸟苷三磷酸从不同的细胞内池诱导钙释放。
FEBS Lett. 1987 Jun 22;218(1):153-8. doi: 10.1016/0014-5793(87)81037-2.
8
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.毒胡萝卜素是一种肿瘤促进剂,它通过特异性抑制内质网Ca2(+)-ATP酶来释放细胞内的Ca2+储备。
Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70. doi: 10.1073/pnas.87.7.2466.
9
The delta isomer of hexachlorocyclohexane induces rapid release of the myo-inositol-1,4,5-trisphosphate-sensitive Ca2+ store and blocks capacitative Ca2+ entry in rat basophilic leukemia cells.六氯环己烷的δ异构体可诱导大鼠嗜碱性白血病细胞中肌醇-1,4,5-三磷酸敏感的Ca2+储存库快速释放Ca2+,并阻断钙池调控性Ca2+内流。
Mol Pharmacol. 1995 Sep;48(3):512-22.
10
Ernst Klenk Lecture, November 1985. Intracellular signalling through inositol trisphosphate and diacylglycerol.恩斯特·克伦克讲座,1985年11月。通过肌醇三磷酸和二酰基甘油的细胞内信号传导。
Biol Chem Hoppe Seyler. 1986 Jun;367(6):447-56.

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Vasorelaxant mechanisms of the antidiabetic anagliptin in rabbit aorta: roles of Kv channels and SERCA pump.抗糖尿病药物阿格列汀对兔主动脉的血管舒张机制:钾离子通道和肌浆网钙ATP酶泵的作用
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VMP1: a multifaceted regulator of cellular homeostasis with implications in disease pathology.VMP1:细胞内稳态的多面调节因子,与疾病病理学相关。
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Impaired Proliferation of CD8 T Cells Stimulated with Monocyte-Derived Dendritic Cells Previously Matured with Thapsigargin-Stimulated LAD2 Human Mast Cells.

本文引用的文献

1
The role of protein kinase C in cell surface signal transduction and tumour promotion.蛋白激酶C在细胞表面信号转导及肿瘤促进中的作用。
Nature. 1984;308(5961):693-8. doi: 10.1038/308693a0.
2
Inositol trisphosphate, a novel second messenger in cellular signal transduction.肌醇三磷酸,细胞信号转导中的一种新型第二信使。
Nature. 1984;312(5992):315-21. doi: 10.1038/312315a0.
3
GTP enhances inositol trisphosphate-stimulated Ca2+ release from rat liver microsomes.鸟苷三磷酸(GTP)增强肌醇三磷酸刺激的大鼠肝脏微粒体Ca2+释放。
经 Thapsigargin 刺激的 LAD2 人肥大细胞预先成熟的单核细胞来源树突状细胞刺激的 CD8 T 细胞增殖受损。
J Immunol Res. 2024 Jul 18;2024:5537948. doi: 10.1155/2024/5537948. eCollection 2024.
4
Two Distinct P2Y Receptors Are Involved in Purine- and Pyrimidine-Evoked Ca Elevation in Mammalian Brain Astrocytic Cultures.两种不同的P2Y受体参与嘌呤和嘧啶引起的哺乳动物脑星形胶质细胞培养物中的钙离子升高。
Drug Dev Res. 2001 Jan-Feb;52(1-2):122-132. doi: 10.1002/ddr.1106.
5
Regulatory mechanisms controlling store-operated calcium entry.控制钙库操纵性钙内流的调节机制。
Front Physiol. 2023 Dec 19;14:1330259. doi: 10.3389/fphys.2023.1330259. eCollection 2023.
6
Shaped by leaky ER: Homeostatic Ca fluxes.由内质网泄漏塑造:稳态钙通量。
Front Physiol. 2022 Sep 7;13:972104. doi: 10.3389/fphys.2022.972104. eCollection 2022.
7
Nanoscale regulation of Ca dependent phase transitions and real-time dynamics of SAP97/hDLG.纳米尺度调控钙依赖性相转变和 SAP97/hDLG 的实时动态。
Nat Commun. 2022 Jul 22;13(1):4236. doi: 10.1038/s41467-022-31912-1.
8
Sigma-1 Receptor Ligands Chlorpromazine and Trifluoperazine Attenuate Ca Responses in Rat Peritoneal Macrophages.西格玛-1受体配体氯丙嗪和三氟拉嗪减弱大鼠腹腔巨噬细胞中的钙反应。
Cell tissue biol. 2022;16(3):233-244. doi: 10.1134/S1990519X22030075. Epub 2022 May 27.
9
Interrogating permeation and gating of Orai channels using chemical modification of cysteine residues.利用半胱氨酸残基的化学修饰来探究 Orai 通道的渗透性和门控性。
Methods Enzymol. 2021;652:213-239. doi: 10.1016/bs.mie.2021.02.012. Epub 2021 Apr 5.
10
From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development.从植物到患者:他普司他汀,一种用于理解天然产物化学、全合成、生物合成、分类学、ATP 酶、细胞死亡和药物开发的工具。
Prog Chem Org Nat Prod. 2021;115:59-114. doi: 10.1007/978-3-030-64853-4_2.
FEBS Lett. 1985 Jun 3;185(1):147-50. doi: 10.1016/0014-5793(85)80759-6.
4
Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+.微量注射肌醇1,3,4,5 - 四磷酸通过一种依赖于细胞外钙离子的机制激活海胆卵。
Biochem J. 1986 Dec 15;240(3):917-20. doi: 10.1042/bj2400917.
5
GTP- and inositol 1,4,5-trisphosphate-activated intracellular calcium movements in neuronal and smooth muscle cell lines.
J Biol Chem. 1987 Oct 5;262(28):13857-64.
6
Platelets and parotid acinar cells have different mechanisms for agonist-stimulated divalent cation entry.血小板和腮腺腺泡细胞对于激动剂刺激的二价阳离子内流具有不同的机制。
J Biol Chem. 1988 May 5;263(13):6161-4.
7
Inositol trisphosphate and diacylglycerol: two interacting second messengers.肌醇三磷酸和二酰甘油:两种相互作用的第二信使。
Annu Rev Biochem. 1987;56:159-93. doi: 10.1146/annurev.bi.56.070187.001111.
8
Inositol phosphates: synthesis and degradation.肌醇磷酸酯:合成与降解
J Biol Chem. 1988 Mar 5;263(7):3051-4.
9
"Calciosome," a cytoplasmic organelle: the inositol 1,4,5-trisphosphate-sensitive Ca2+ store of nonmuscle cells?“钙小体”,一种细胞质细胞器:非肌肉细胞中对肌醇1,4,5 -三磷酸敏感的钙储存库?
Proc Natl Acad Sci U S A. 1988 Feb;85(4):1091-5. doi: 10.1073/pnas.85.4.1091.
10
Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relation to AIDS.毒胡萝卜素对与艾滋病相关的人淋巴细胞胞质钙离子及增殖的影响。
Biochim Biophys Acta. 1988 Dec 9;972(3):257-64. doi: 10.1016/0167-4889(88)90200-5.