Krivosic-Horber R, Reyfort H, Becq M C, Adnet P
Département d'Anesthésie Réanimation Chirurgical I, Hôpital B, Centre Hospitalier Régional Universitaire, Lille, France.
Br J Anaesth. 1989 Jun;62(6):691-3. doi: 10.1093/bja/62.6.691.
Anaesthetic techniques for malignant hyperthermia susceptible (MHS) patients should include drugs which do not trigger MH and provide stress free conditions. Thus all new drugs should be screened for their susceptibility to trigger MH. We have screened propofol, using the MHS pig model. In none of the animals exposed to propofol, were there signs of MH, even after challenge with suxamethonium. However, the same animals developed MH when exposed to halothane alone or with suxamethonium. Despite the problems of extrapolating from this study to man, it is unlikely that propofol may trigger an episode of MH.
对于恶性高热易感（MHS）患者，麻醉技术应包括使用不会引发恶性高热的药物，并提供无应激的条件。因此，所有新药都应进行是否易引发恶性高热的筛查。我们使用MHS猪模型对丙泊酚进行了筛查。在所有接触丙泊酚的动物中，即使在使用琥珀胆碱激发后，也没有出现恶性高热的迹象。然而，相同的动物在单独接触氟烷或与琥珀胆碱一起接触时会发生恶性高热。尽管从这项研究推断到人类存在问题，但丙泊酚引发恶性高热发作的可能性不大。
