Short C E, Paddleford R R, McGrath C J, Williams C H
Anesth Analg. 1976 Sep-Oct;55(5):643-53. doi: 10.1213/00000539-197609000-00007.
Fifty-three swine from the University of Missouri Sinclair Medical Research Farm were used in experimentation to determine their susceptibility to malignant hyperthermia, to determine appropriate anesthetic agents for susceptible swine and to investigate appropriate pharmaceutical agents which could protect against the development of malignant hyperthermia. The screening technics used were successful in determining susceptible animals to MH and the anesthesia studies indicated that dissociative anesthetics had less tendency to trigger MH than did halothane and pancuronium was shown to have greater safety as a muscle relaxant than succinylcholine in this group of pigs. Pigs pretreated with reserpine had less tendency to develop symptoms of MH and some were completely protected. The principle undesirable effect was the development of hypotension if sufficient reserpine was used to provide total protection.
来自密苏里大学辛克莱医学研究农场的53头猪被用于实验，以确定它们对恶性高热的易感性，确定适合易感猪的麻醉剂，并研究能够预防恶性高热发生的合适药物。所使用的筛选技术成功地确定了对恶性高热易感的动物，麻醉研究表明，与氟烷相比，解离麻醉剂引发恶性高热的倾向较小，并且在这组猪中，泮库溴铵作为肌肉松弛剂比琥珀酰胆碱具有更高的安全性。用利血平预处理的猪出现恶性高热症状的倾向较小，有些猪得到了完全保护。主要的不良影响是，如果使用足够的利血平来提供全面保护，会出现低血压。
