人类感染乙肝病毒后远程感染对乙肝表面抗原（HBsAg）体外免疫反应的抗独特型调节
Anti-idiotype modulation of the in vitro immune response to hepatitis B surface antigen (HBsAg) following remote infection by hepatitis B virus in man.
作者信息
Cupps T R, Haas-Smith S A, Gerin J L, Tibbles J L, Kennedy R C
机构信息
Department of Medicine, Georgetown University Medical Center, Washington, D.C. 20007.
出版信息
Cell Immunol. 1989 Aug;122(1):244-50. doi: 10.1016/0008-8749(89)90164-0.
An antigen-inhibitable Ab-2 that exhibits internal image activity will selectively stimulate the in vitro production of anti-HBs in individuals with remotely established immunity to hepatitis B virus. This response is seen (1) in the absence of a polyconal increase in total IgG, (2) with the F(ab')2 component of the Ab-2, (3) in cultures depleted of T-cells, and (4) in the absence of stimulation by antigen. This observation demonstrates that the Ab-2-mediated stimulation of specific IgG production may be an important regulatory function in man.
一种具有内影像活性的抗原可抑制性Ab-2将选择性地刺激对乙型肝炎病毒具有远期免疫力的个体体外抗-HBs的产生。这种反应表现为：（1）总IgG无多克隆性增加；（2）与Ab-2的F(ab')2成分有关；（3）在T细胞耗竭的培养物中；（4）在无抗原刺激的情况下。这一观察结果表明，Ab-2介导的特异性IgG产生的刺激可能是人体中的一种重要调节功能。
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