增强对乙型肝炎表面抗原的免疫反应。抗独特型抗体的体内给药可诱导表达相似独特型的抗-HBs。
Enhancement of the immune response to hepatitis B surface antigen. In vivo administration of antiidiotype induces anti-HBs that expresses a similar idiotype.
作者信息
Kennedy R C, Dreesman G R
出版信息
J Exp Med. 1984 Mar 1;159(3):655-65. doi: 10.1084/jem.159.3.655.
Abstract
BALB/c mice receiving antiidiotype antibodies before the injection of hepatitis B surface antigen (HBsAg) generated an enhanced anti-HBs response. Mice given antiidiotype antibodies in a soluble form induced predominantly IgM anti-HBs, whereas alum-precipitated antiidiotype produced primarily IgG anti-HBs. Injection of antiidiotype antibodies alone induced anti-HBs that inhibited a common interspecies anti-HBs idiotype-antiidiotype reaction and recognized the group-specific determinant of HBsAg. These data support the view that antiidiotype antibodies may modulate the immune response to an infectious viral agent.
摘要
在注射乙肝表面抗原（HBsAg）之前接受抗独特型抗体的BALB/c小鼠产生了增强的抗-HBs反应。以可溶性形式给予抗独特型抗体的小鼠主要诱导产生IgM抗-HBs，而明矾沉淀的抗独特型抗体主要产生IgG抗-HBs。单独注射抗独特型抗体诱导产生的抗-HBs抑制了常见的种间抗-HBs独特型-抗独特型反应，并识别HBsAg的群特异性决定簇。这些数据支持抗独特型抗体可能调节对感染性病毒病原体的免疫反应这一观点。
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