Kennedy R C, Adler-Storthz K, Henkel R D, Sanchez Y, Melnick J L, Dreesman G R
Science. 1983 Aug 26;221(4613):853-5. doi: 10.1126/science.6603657.
Anti-idiotype reagents that recognize a common idiotype associated with the combining site of antibodies to hepatitis B surface antigen (anti-HBs) were used to manipulate the immune response to hepatitis B surface antigen in BALB/c mice. The injection of antibodies to the idiotype before antigenic stimulation resulted in an increase in the number of cells secreting immunoglobulin M antibodies to hepatitis B surface antigen. Anti-HBs-secreting cells were also induced by administration of antibodies to the idiotype without subsequent antigen exposure. These findings indicate that the immune response to hepatitis B surface antigen in mice is regulated through an idiotype-anti-idiotype network.
识别与乙肝表面抗原（抗-HBs）抗体结合位点相关的共同独特型的抗独特型试剂，被用于调控BALB/c小鼠对乙肝表面抗原的免疫反应。在抗原刺激前注射针对该独特型的抗体，导致分泌针对乙肝表面抗原的免疫球蛋白M抗体的细胞数量增加。在没有后续抗原暴露的情况下，给予针对该独特型的抗体也能诱导产生分泌抗-HBs的细胞。这些发现表明，小鼠对乙肝表面抗原的免疫反应是通过独特型-抗独特型网络来调节的。
