羟基磷灰石纳米颗粒：制备方法及医学应用
Hydroxylapatite nanoparticles: fabrication methods and medical applications.
作者信息
Okada Masahiro, Furuzono Tsutomu
机构信息
Department of Biomaterials, Osaka Dental University, 8-1 Kuzuha-Hanazono, Hirakata, Osaka, 573-1121, Japan.
Department of Biomedical Engineering, School of Biology-Oriented Science and Technology, Kinki University, 930 Nishi-Mitani, Kinokawa, Wakayama, 649-6493, Japan.
出版信息
Sci Technol Adv Mater. 2012 Dec 28;13(6):064103. doi: 10.1088/1468-6996/13/6/064103. eCollection 2012 Dec.
Hydroxylapatite (or hydroxyapatite, HAp) exhibits excellent biocompatibility with various kinds of cells and tissues, making it an ideal candidate for tissue engineering, orthopedic and dental applications. Nanosized materials offer improved performances compared with conventional materials due to their large surface-to-volume ratios. This review summarizes existing knowledge and recent progress in fabrication methods of nanosized (or nanostructured) HAp particles, as well as their recent applications in medical and dental fields. In section 1, we provide a brief overview of HAp and nanoparticles. In section 2, fabrication methods of HAp nanoparticles are described based on the particle formation mechanisms. Recent applications of HAp nanoparticles are summarized in section 3. The future perspectives in this active research area are given in section 4.
羟基磷灰石（或羟磷灰石，HAp）与各种细胞和组织具有优异的生物相容性，使其成为组织工程、骨科和牙科应用的理想候选材料。由于纳米材料具有较大的表面体积比，与传统材料相比，它们具有更好的性能。本综述总结了纳米级（或纳米结构）HAp颗粒制备方法的现有知识和最新进展，以及它们在医学和牙科领域的最新应用。在第1节中，我们简要概述了HAp和纳米颗粒。在第2节中，基于颗粒形成机制描述了HAp纳米颗粒的制备方法。第3节总结了HAp纳米颗粒的最新应用。第4节给出了这一活跃研究领域的未来展望。
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