Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA.
Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA; Department of Periodontics, College of Dentistry and Dental Clinics, University of Iowa, Iowa City, IA, USA.
Eur J Pharm Biopharm. 2021 Apr;161:15-28. doi: 10.1016/j.ejpb.2021.01.018. Epub 2021 Feb 5.
Tissue engineering is an interdisciplinary field that aims to combine life sciences and engineering to create therapies that regenerate functional tissue. Early work in tissue engineering mostly used materials as inert scaffolding structures, but research has shown that constructing scaffolds from biologically active materials can help with regeneration by enabling cell-scaffold interactions or release of factors that aid in regeneration. Three-dimensional (3D) printing is a promising technique for the fabrication of structurally intricate and compositionally complex tissue engineering scaffolds. Such scaffolds can be functionalized with techniques developed by nanotechnology research to further enhance their ability to stimulate regeneration and interact with cells. Nanotechnological components, nanoscale textures, and microscale/nanoscale printing can all be incorporated into the manufacture of 3D printed scaffolds. This review discusses recent advancements in the merging of nanotechnology with 3D printed tissue engineering scaffolds, with a focus on applications of nanoscale components, nanoscale texture, and innovative printing techniques and the effects observed in vitro and in vivo.
组织工程是一门跨学科领域，旨在将生命科学和工程学结合起来，创造出能够再生功能性组织的治疗方法。早期的组织工程工作主要使用材料作为惰性支架结构，但研究表明，构建由生物活性材料组成的支架可以通过促进细胞-支架相互作用或释放有助于再生的因子来帮助再生。三维（3D）打印是制造结构复杂和组成复杂的组织工程支架的有前途的技术。可以通过纳米技术研究开发的技术对这些支架进行功能化，以进一步增强其刺激再生和与细胞相互作用的能力。纳米技术组件、纳米级纹理和微/纳米级打印都可以被纳入 3D 打印支架的制造中。本文综述了纳米技术与 3D 打印组织工程支架融合的最新进展，重点介绍了纳米级组件、纳米级纹理和创新打印技术的应用，以及在体外和体内观察到的效果。
