Wagner Martin, Tiffe Theresa, Morbach Caroline, Gelbrich Götz, Störk Stefan, Heuschmann Peter U
1 Institute of Clinical Epidemiology and Biometry, University of Würzburg, Germany.
2 Comprehensive Heart Failure Center, University of Würzburg, Germany.
Eur J Prev Cardiol. 2017 Mar;24(5):468-479. doi: 10.1177/2047487316680693. Epub 2016 Nov 23.
Background Data from the general population on the natural course of heart failure is lacking. The objectives of the STAAB cohort study are to determine the prevalence of heart failure stages A-B in a representative sample of the general population and to prospectively investigate the progression from asymptomatic cardiac dysfunction into symptomatic heart failure. Here we present study design, participation rates and baseline characteristics of the first 1468 enrolled subjects. Methods A random sample of inhabitants from the city of Würzburg stratified by age (30-79 years) and gender was drawn from the local registration office. Subjects receive invitation letters, while send-out batches are continuously adapted to response rates by age and gender. At baseline examination, data on echocardiographic cardiac function, comorbidities and preclinical cardiovascular phenotypes are collected. After 3-5 years, changes in cardiac function and occurrence of clinical events will be assessed in a follow-up visit. Results Between December 2013 and April 2015, 4499 subjects were invited; of those, 1510 (34.6%) responded positively, and 1468 were examined (32.6%). Stratified recruitment was on-target while the participation rate was highest in subjects aged 60-69 years (38%). Hypertension (42%) and dyslipidaemia (37%) were the most commonly reported comorbidities; 7% reported on diabetes and 23% of men ( vs. 17% of women) were smokers. Conclusions STAAB recruits a representative population-based sample suited to provide reliable estimates of the frequency of asymptomatic cardiac dysfunction and determinants of disease progression into symptomatic heart failure. These findings will build the ground for developing preventive strategies for heart failure at different stages of the disease continuum.
缺乏来自普通人群中心力衰竭自然病程的数据。STAAB队列研究的目的是确定普通人群代表性样本中心力衰竭A - B期的患病率，并前瞻性地研究从无症状心脏功能障碍进展为有症状心力衰竭的情况。在此，我们展示了前1468名入组受试者的研究设计、参与率和基线特征。方法：从维尔茨堡市当地户籍登记处抽取按年龄（30 - 79岁）和性别分层的居民随机样本。向受试者发送邀请信，同时根据年龄和性别的回复率不断调整发送批次。在基线检查时，收集超声心动图心脏功能、合并症和临床前心血管表型的数据。3 - 5年后，在随访中评估心脏功能变化和临床事件的发生情况。结果：在2013年12月至2015年4月期间，邀请了4499名受试者；其中，1510名（34.6%）做出了积极回应，1468名接受了检查（32.6%）。分层招募达到了目标，参与率在60 - 69岁的受试者中最高（38%）。高血压（42%）和血脂异常（37%）是最常报告的合并症；7%报告患有糖尿病，23%的男性（相比17%的女性）为吸烟者。结论：STAAB招募了一个具有代表性的基于人群的样本，适合提供无症状心脏功能障碍频率以及疾病进展为有症状心力衰竭的决定因素的可靠估计。这些发现将为制定疾病连续统一体不同阶段心力衰竭的预防策略奠定基础。
