白细胞介素-1β和白细胞介素-1α对产热和发热的中枢激活涉及不同机制。

Central activation of thermogenesis and fever by interleukin-1 beta and interleukin-1 alpha involves different mechanisms.

作者信息

Busbridge N J, Dascombe M J, Tilders F J, van Oers J W, Linton E A, Rothwell N J

机构信息

Department of Physiological Sciences, University of Manchester, UK.

出版信息

Biochem Biophys Res Commun. 1989 Jul 31;162(2):591-6. doi: 10.1016/0006-291x(89)92351-6.

DOI:10.1016/0006-291x(89)92351-6

PMID:2787987

Abstract

Interleukin-1 exists in two forms (alpha and beta) which are assumed to act on the same receptor. Both forms of the molecule stimulated fever and thermogenesis in the rat when injected into the brain, but interleukin-1 beta was more effective, and combined injection of alpha and beta elicited additive responses. The actions of interleukin-1 beta were inhibited by pretreatment of the animals with either a receptor antagonist or monoclonal antibody to corticotrophin releasing factor. The effects of interleukin-1 alpha were unaltered by these treatments. The results indicate that brain corticotrophin releasing factor mediates thermogenesis and fever induced by interleukin-1 beta but not by interleukin-1 alpha.

摘要

白细胞介素-1以两种形式（α和β）存在，假定它们作用于同一受体。将这两种分子形式注入大鼠脑内时均能刺激发热和产热，但白细胞介素-1β的效果更强，α和β联合注射会产生相加反应。用促肾上腺皮质激素释放因子的受体拮抗剂或单克隆抗体对动物进行预处理可抑制白细胞介素-1β的作用。这些处理对白细胞介素-1α的作用没有影响。结果表明，脑促肾上腺皮质激素释放因子介导白细胞介素-1β诱导的产热和发热，而不介导白细胞介素-1α诱导的产热和发热。