一名营养不良儿童的喉部爱泼斯坦-巴尔病毒相关平滑肌肿瘤
Laryngeal Epstein-Barr Virus-Associated Smooth Muscle Tumor in an Undernourished Child.
作者信息
Soares Ciro Dantas, Carlos Roman, Molina Juan Pablo Díaz, de Lima Morais Thayná Melo, de Almeida Oslei Paes
机构信息
Oral Pathology, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira 901, PO Box 52, Piracicaba, São Paulo, 13414-903, Brazil.
Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Ciudad de Guatemala, Guatemala.
出版信息
Head Neck Pathol. 2019 Dec;13(4):722-726. doi: 10.1007/s12105-018-0960-0. Epub 2018 Aug 17.
Abstract
Smooth muscle tumors associated with Epstein-Barr virus infections (EBV-SMT) of laryngeal origin are exceedingly rare and have been reported in few adult patients, but not in children. This reported case describes a lesion found in the larynx of an 8-year-old Guatemalan undernourished girl. Microscopically, the lesion showed a highly cellular mesenchymal spindle cell tumor, containing frequent lymphocytes. The immunohistochemical analysis revealed positivity for α-smooth muscle actin and h-caldesmon. In addition, most of the tumor cells were positive for EBV by in situ hybridization. To the best of the author's knowledge, this is the first literature-reported case of laryngeal EBV-SMT occurring in an undernourished child.
摘要
与爱泼斯坦-巴尔病毒感染相关的喉部平滑肌肿瘤（EBV-SMT）极为罕见，仅在少数成年患者中有报道，儿童患者中尚未见报道。本报告病例描述了一名8岁危地马拉营养不良女童喉部发现的病变。显微镜下，该病变显示为高度细胞性的间叶性梭形细胞瘤，伴有大量淋巴细胞。免疫组化分析显示α-平滑肌肌动蛋白和h-钙调蛋白呈阳性。此外，通过原位杂交检测，大多数肿瘤细胞EBV呈阳性。据作者所知，这是文献报道的首例发生在营养不良儿童中的喉部EBV-SMT病例。
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本文引用的文献
1
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Clin Nucl Med. 2017 Oct;42(10):770-772. doi: 10.1097/RLU.0000000000001794.
2
Epstein-Barr Virus in Nasopharyngeal Carcinoma of Guatemalan and Brazilian Patients.危地马拉和巴西患者鼻咽癌中的爱泼斯坦-巴尔病毒
Int J Surg Pathol. 2017 Jun;25(4):304-309. doi: 10.1177/1066896916679518. Epub 2016 Nov 23.
3
Epstein-Barr Virus: Diseases Linked to Infection and Transformation.爱泼斯坦-巴尔病毒：与感染和转化相关的疾病
Front Microbiol. 2016 Oct 25;7:1602. doi: 10.3389/fmicb.2016.01602. eCollection 2016.
4
Epstein-Barr Virus-Associated Smooth Muscle Tumor.爱泼斯坦-巴尔病毒相关的平滑肌瘤
Arch Pathol Lab Med. 2016 Jul;140(7):718-22. doi: 10.5858/arpa.2015-0120-RS.
5
Immune Dysfunction as a Cause and Consequence of Malnutrition.免疫功能障碍作为营养不良的原因和后果
Trends Immunol. 2016 Jun;37(6):386-398. doi: 10.1016/j.it.2016.04.003. Epub 2016 May 26.
6
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7
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8
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9
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10
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Eur J Cancer. 2014 Sep;50(14):2417-24. doi: 10.1016/j.ejca.2014.06.006. Epub 2014 Jul 11.
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