Soares Ciro Dantas, Carlos Roman, Molina Juan Pablo Díaz, de Lima Morais Thayná Melo, de Almeida Oslei Paes
Oral Pathology, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira 901, PO Box 52, Piracicaba, São Paulo, 13414-903, Brazil.
Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Ciudad de Guatemala, Guatemala.
Head Neck Pathol. 2019 Dec;13(4):722-726. doi: 10.1007/s12105-018-0960-0. Epub 2018 Aug 17.
Smooth muscle tumors associated with Epstein-Barr virus infections (EBV-SMT) of laryngeal origin are exceedingly rare and have been reported in few adult patients, but not in children. This reported case describes a lesion found in the larynx of an 8-year-old Guatemalan undernourished girl. Microscopically, the lesion showed a highly cellular mesenchymal spindle cell tumor, containing frequent lymphocytes. The immunohistochemical analysis revealed positivity for α-smooth muscle actin and h-caldesmon. In addition, most of the tumor cells were positive for EBV by in situ hybridization. To the best of the author's knowledge, this is the first literature-reported case of laryngeal EBV-SMT occurring in an undernourished child.
与爱泼斯坦-巴尔病毒感染相关的喉部平滑肌肿瘤（EBV-SMT）极为罕见，仅在少数成年患者中有报道，儿童患者中尚未见报道。本报告病例描述了一名8岁危地马拉营养不良女童喉部发现的病变。显微镜下，该病变显示为高度细胞性的间叶性梭形细胞瘤，伴有大量淋巴细胞。免疫组化分析显示α-平滑肌肌动蛋白和h-钙调蛋白呈阳性。此外，通过原位杂交检测，大多数肿瘤细胞EBV呈阳性。据作者所知，这是文献报道的首例发生在营养不良儿童中的喉部EBV-SMT病例。
