胰岛素诱导的自身免疫综合征：一例报告。
Insulin-induced autoimmune syndrome: A case report.
作者信息
Chu Jian-Ping, Zheng Xiao-Wei, Lu Jie, Zhong Jin-Yan, Li Jia-Lin, Xu Miao, Lin Fang
机构信息
Department of Endocrinology, Ningbo First Hospital, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
出版信息
Exp Ther Med. 2016 Nov;12(5):3359-3362. doi: 10.3892/etm.2016.3767. Epub 2016 Oct 3.
Abstract
Insulin autoimmune syndrome (IAS) is a disease characterized by hyperinsulinemic hypoglycemia associated with autoantibodies against endogenous insulin. A 56-year-old man was admitted to Ningbo First Hospital for the treatment of spontaneous hypoglycemia. He was found to have elevated fasting insulin level (>1,000 mIU/l) and presence of insulin autoantibodies, and after appropriate workup, was diagnosed with IAS. After treating with prednisone for 2 months, his insulin level started decreasing. In patients with repeated hypoglycemia, IAS should be considered in the differential diagnosis. Prednisone may be effective for the treatment of hypoglycemia in patients with IAS.
摘要
胰岛素自身免疫综合征（IAS）是一种以高胰岛素血症性低血糖伴内源性胰岛素自身抗体为特征的疾病。一名56岁男性因自发性低血糖入住宁波市第一医院治疗。发现其空腹胰岛素水平升高（>1000 mIU/l）且存在胰岛素自身抗体，经过适当检查后，被诊断为IAS。使用泼尼松治疗2个月后，他的胰岛素水平开始下降。对于反复发生低血糖的患者，鉴别诊断时应考虑IAS。泼尼松可能对IAS患者的低血糖治疗有效。
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