作为组织再生载体的微泡：守护者的更替
Microvesicles as Vehicles for Tissue Regeneration: Changing of the Guards.
作者信息
Panagiotou Nikolaos, Wayne Davies R, Selman Colin, Shiels Paul G
机构信息
Wolfson Wohl, Translational Research Centre, Institute of Cancer Sciences, MVLS, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1QH UK.
School of Informatics, Institute of Neural and Adaptive Computation, Informatics Forum, University of Edinburgh, 10 Crichton Street, Edinburgh, EH8 9AB UK.
出版信息
Curr Pathobiol Rep. 2016;4(4):181-187. doi: 10.1007/s40139-016-0115-5. Epub 2016 Aug 27.
PURPOSE OF REVIEW
Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects.
RECENT FINDINGS
MVs constitute one unique size class of extracellular vesicles (EVs) directly shed from the cell plasma membrane. They facilitate cell-to-cell communication via intercellular transfer of proteins, mRNA and microRNA (miRNA). MVs derived from stem cells, or stem cell regulatory cell types, have proven roles in tissue regeneration and repair processes. Their role in the maintenance of healthy tissue function throughout the life course and thus in age related health span remains to be elucidated.
SUMMARY
Understanding the biogenesis and mechanisms of action of MVs may enable the development of cell-free therapeutics capable of assisting in tissue maintenance and repair for a variety of age-related degenerative diseases. This review critically evaluates recent work published in this area and highlights important new findings demonstrating the use of MVs in tissue regeneration.
综述目的
微泡（MVs）已被认为是干细胞功能的介质，能够实现并引导其再生效应。
最新发现
微泡是直接从细胞质膜脱落的一类独特大小的细胞外囊泡（EVs）。它们通过蛋白质、mRNA和微小RNA（miRNA）的细胞间转移促进细胞间通讯。源自干细胞或干细胞调节细胞类型的微泡在组织再生和修复过程中已被证实发挥作用。它们在整个生命过程中维持健康组织功能以及与年龄相关的健康寿命方面的作用仍有待阐明。
总结
了解微泡的生物发生和作用机制可能有助于开发无细胞疗法，以协助各种与年龄相关的退行性疾病的组织维持和修复。本综述批判性地评估了该领域最近发表的研究工作，并突出了显示微泡在组织再生中应用的重要新发现。
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