Maricq H R, Weinrich M C, Keil J E, Smith E A, Harper F E, Nussbaum A I, LeRoy E C, McGregor A R, Diat F, Rosal E J
Department of Medicine, Medical University of South Carolina, Charleston 29425.
Arthritis Rheum. 1989 Aug;32(8):998-1006. doi: 10.1002/anr.1780320809.
The prevalence of scleroderma spectrum disorders (including systemic sclerosis [SSc] meeting the American Rheumatism Association criteria and the less typical disorders meeting only our study criteria) was determined in a random sample of 6,998 subjects from the general population of South Carolina. The results suggest that the prevalence of these disorders may range from 67 to 265 per 100,000, which is 4.9 to 19.2 times higher than previously reported for definite SSc. The ratio of nondefinite cases to definite cases of SSc (those meeting American Rheumatism Association criteria) was 2.5. Most of the nondefinite cases were unrecognized prior to our study, which suggests the need for improved early diagnosis of scleroderma spectrum disorders. Brief histories of the 7 patients with scleroderma spectrum disorders whose cases formed the basis for our calculation of prevalence rates are included in this report.
在南卡罗来纳州普通人群的6998名随机抽样受试者中，确定了硬皮病谱系障碍（包括符合美国风湿病协会标准的系统性硬化症[SSc]以及仅符合我们研究标准的不太典型的疾病）的患病率。结果表明，这些疾病的患病率可能为每10万人67至265例，这比之前报道的确诊SSc患病率高4.9至19.2倍。SSc非确诊病例与确诊病例（符合美国风湿病协会标准的病例）的比例为2.5。大多数非确诊病例在我们的研究之前未被识别，这表明需要改进硬皮病谱系障碍的早期诊断。本报告包括了7例硬皮病谱系障碍患者的简要病史，这些病例构成了我们计算患病率的基础。
