Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA.
Adv Mater. 2017 Jan;29(4). doi: 10.1002/adma.201604043. Epub 2016 Nov 25.
A thrombin-responsive closed-loop patch is developed for prolonged heparin delivery in a feedback-controlled manner. This microneedle-based patch can sense activated thrombin and subsequently releases heparin to prevent coagulation in the blood flow. This "smart" heparin patch can be transcutaneously inserted into skin without drug leakage and can sustainably regulate blood coagulation in response to thrombin.
一种凝血酶响应型闭环贴片被开发出来,用于以反馈控制方式延长肝素的释放。这种基于微针的贴片可以感知激活的凝血酶,并随后释放肝素以防止血流中的凝血。这种“智能”肝素贴片可以经皮插入皮肤而不会发生药物泄漏,并可以持续响应凝血酶调节血液凝固。