在纳米尺度上重建组织的组成、结构和功能以用于再生医学。
Recreating composition, structure, functionalities of tissues at nanoscale for regenerative medicine.
作者信息
Alarçin Emine, Guan Xiaofei, Kashaf Sara Saheb, Elbaradie Khairat, Yang Huazhe, Jang Hae Lin, Khademhosseini Ali
机构信息
Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women's Hospital, Boston, MA 02139, USA.
Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Regen Med. 2016 Dec;11(8):849-858. doi: 10.2217/rme-2016-0120. Epub 2016 Nov 25.
Nanotechnology offers significant potential in regenerative medicine, specifically with the ability to mimic tissue architecture at the nanoscale. In this perspective, we highlight key achievements in the nanotechnology field for successfully mimicking the composition and structure of different tissues, and the development of bio-inspired nanotechnologies and functional nanomaterials to improve tissue regeneration. Numerous nanomaterials fabricated by electrospinning, nanolithography and self-assembly have been successfully applied to regenerate bone, cartilage, muscle, blood vessel, heart and bladder tissue. We also discuss nanotechnology-based regenerative medicine products in the clinic for tissue engineering applications, although so far most of them are focused on bone implants and fillers. We believe that recent advances in nanotechnologies will enable new applications for tissue regeneration in the near future.
纳米技术在再生医学领域具有巨大潜力，特别是能够在纳米尺度上模拟组织结构。从这个角度来看，我们重点介绍了纳米技术领域在成功模拟不同组织的组成和结构方面取得的关键成就，以及受生物启发的纳米技术和功能性纳米材料的发展，以促进组织再生。通过静电纺丝、纳米光刻和自组装制备的众多纳米材料已成功应用于骨、软骨、肌肉、血管、心脏和膀胱组织的再生。我们还讨论了临床上用于组织工程应用的基于纳米技术的再生医学产品，尽管到目前为止其中大多数都集中在骨植入物和填充物上。我们相信，纳米技术的最新进展将在不久的将来为组织再生带来新的应用。
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