Vozianov A F, Drannik G N, Montag T S, Khoroshun D I, Pavlenko E P
Urol Nefrol (Mosk). 1989 May-Jun(3):11-4.
The interrelation between transplantation antigens of the HLA system and predisposition to acute pyelonephritis (PN) were studied in 81 patients, of them 36 with acute serous PN and 45 with acute purulent PN. HLA phenotype was identified with a routine lymphocytotoxic microtest in which a home-made typing panel of HLA antiserum to antigens of A and B loci was used. 150 healthy donors were subjected to control typing. Variance in HLA frequency reliability in patients and controls was verified with chi 2 criterion for tables 2 X 2. The study demonstrated higher frequency of B8 and B14 and lower of Aw19 and B35 antigens in patients with PN versus the healthy controls. Differential analysis with regard to the clinical course of the disease revealed that predisposition to acute serous PN was associated with the occurrence of A3 and B14 antigens while A10 and B8 antigens were indicative of acute purulent PN. It has been stated that purulent PN is developing in presence of secondary deficiency of T and B immune systems. Cross-reacting antigens B14 and B8, as well as splitting antigens A10 and A25 lend more ground to varying clinical course of the disease. HLA antigen B35 is found associated with the development of acute PN resistance.
对81例患者研究了HLA系统移植抗原与急性肾盂肾炎（PN）易感性之间的相互关系，其中36例为急性浆液性PN，45例为急性化脓性PN。采用常规淋巴细胞毒性微量试验鉴定HLA表型，该试验使用了自制的针对A和B位点抗原的HLA抗血清分型板。150名健康供者接受对照分型。用2×2表的卡方检验验证患者和对照中HLA频率可靠性的差异。研究表明，与健康对照相比，PN患者中B8和B14抗原频率较高，而Aw19和B35抗原频率较低。对疾病临床过程的差异分析显示，急性浆液性PN的易感性与A3和B14抗原的出现有关，而A10和B8抗原提示急性化脓性PN。据称，化脓性PN是在T和B免疫系统继发性缺陷的情况下发生的。交叉反应抗原B14和B8，以及分裂抗原A10和A25为疾病不同的临床过程提供了更多依据。发现HLA抗原B35与急性PN抵抗力的发展有关。
