dell'Omo Roberto, Virgili Gianni, Rizzo Stanislao, De Turris Serena, Coclite Giovanni, Giorgio Dario, dell'Omo Ermanno, Costagliola Ciro
Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy; Casa di Cura "Villa Maria", Campobasso, Italy.
Department of Translational Surgery and Medicine, University of Florence, Florence, Italy.
Am J Ophthalmol. 2017 Mar;175:16-29. doi: 10.1016/j.ajo.2016.11.007. Epub 2016 Nov 24.
To compare the morphologic and functional characteristics and response to surgery of lamellar macular holes (LMHs) with and without lamellar hole-associated epiretinal proliferation (LHEP) and standard epiretinal membrane (ERM).
Retrospective observational case series.
Setting: Vitreoretinal clinical practice.
Eigthy-four eyes of 84 patients. The included eyes must present an irregular foveal contour and schitic or cavitated lamellar separation of neurosensory retina on spectral-domain optical coherence tomography (SDOCT) and an area of increased autofluorescence on blue fundus autofluorescence (B-FAF). Twenty-six eyes underwent pars plana vitrectomy (PPV).
Logarithm of minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) and evolution of morphologic characteristics.
Standard ERM alone, LHEP alone, and concomitant ERM and LHEP were found in 51.2%, 13.1%, and 35.7% of the cases, respectively. A substantial stability of functional and morphologic parameters throughout the follow-up period was observed in the eyes that did not undergo surgery indipendently from the associated epiretinal material. The most significant change, observed in the preoperative period, in the eyes that underwent surgery, was the thinning of the central foveal thickness (CFT, P < .001). In the operated eyes, logMAR BCVA continuosly improved during the postoperative period (P = .006), CFT was found increased, and diameters of the hole were found reduced since the first month after operation (P < .001).
In eyes with LMHs, presence of LHEP without any trace of standard ERM is rare. The presence of LHEP does not seem to influence the natural course of the disease and the response to surgery.
比较伴有和不伴有板层孔相关视网膜前增殖（LHEP）的板层黄斑孔（LMH）以及标准视网膜前膜（ERM）的形态学和功能特征及手术反应。
回顾性观察病例系列。
地点：玻璃体视网膜临床实践。
84例患者的84只眼。纳入的眼睛在光谱域光学相干断层扫描（SDOCT）上必须呈现不规则的黄斑中心凹轮廓以及神经感觉视网膜的劈裂或空泡状板层分离，并且在蓝色眼底自发荧光（B-FAF）上有自发荧光增强区域。26只眼接受了玻璃体切割术（PPV）。
最小分辨角对数（logMAR）最佳矫正视力（BCVA）和形态学特征的演变。
分别在51.2%、13.1%和35.7%的病例中发现单独的标准ERM、单独的LHEP以及合并的ERM和LHEP。在未接受手术的眼中，无论相关视网膜前物质如何，在整个随访期间功能和形态学参数都有显著稳定性。在接受手术的眼中，术前观察到的最显著变化是中心凹厚度（CFT）变薄（P < .001）。在手术眼中，logMAR BCVA在术后持续改善（P = .006），CFT增加，并且自手术后第一个月起孔的直径减小（P < .001）。
在患有LMH的眼中，存在无任何标准ERM痕迹的LHEP情况罕见。LHEP的存在似乎不影响疾病的自然病程和手术反应。
