Gao Yuzhu, Zhang Yifan, Gao Yunxia, Mou Kefan, Liu Yilin, Xu Hanyue, Man Shulei, Chen Yi, Chen Lin, Huang Yufan, An Jingqi, Huo Tianpeng, Zhang Jie, Zhang Ming
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Ophthalmology and Research Laboratory of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):22. doi: 10.1167/iovs.66.11.22.
To evaluate adaptive optics scanning laser ophthalmoscope (AO-SLO) features and identify their multimodal retinal imaging characteristics using AO-SLO, swept-source optical coherence tomography (SS-OCT), and color fundus photography in patients undergoing surgery for epiretinal membrane (ERM), and to provide valuable insights into the mechanism underlying postoperative ERM progression.
Patients with ERM underwent multimodal retinal imaging following surgery, including color fundus photography, SS-OCT, and AO-SLO. AO-SLO features were characterized, and their corresponding multimodal retinal imaging findings were analyzed.
Seventeen eyes from 17 postoperative ERM patients were included in this pilot study (mean age [SD], 68.06 [8.26] years; 12 female [70.6%]). Seven categories of AO-SLO features were identified in patients with ERM after surgery. The most common features were granular membrane (n = 17 [100%]), waxy membrane (n = 12 [70.6%]), and microcysts (n = 12 [70.6%]), after dissociated optic nerve fiber layer (n = 11 [64.7%]), microfolds (n = 6 [35.3%]), punctate reflectivity (n = 6 [35.3%]), and retinal folds (n = 5 [29.4%]).
AO-SLO imaging provides detailed insights into retinal microstructural changes after surgery for ERM. Further longitudinal studies tracking AO-SLO features over time and integrating multimodal retinal imaging modalities could enhance our understanding of retinal restoration processes and improve the prediction of surgical outcomes in ERM.
使用自适应光学扫描激光检眼镜（AO-SLO）、扫频光学相干断层扫描（SS-OCT）和彩色眼底照相术，评估接受视网膜前膜（ERM）手术患者的AO-SLO特征，并确定其多模态视网膜成像特征，以深入了解术后ERM进展的潜在机制。
ERM患者术后接受多模态视网膜成像检查，包括彩色眼底照相术、SS-OCT和AO-SLO。对AO-SLO特征进行表征，并分析其相应的多模态视网膜成像结果。
本前瞻性研究纳入了17例ERM术后患者的17只眼（平均年龄[标准差]，68.06[8.26]岁；女性12例[70.6%]）。术后ERM患者中识别出七类AO-SLO特征。最常见的特征是颗粒状膜（n = 17[100%]）、蜡样膜（n = 12[70.6%]）和微囊肿（n = 12[70.6%]），其次是分离的视神经纤维层（n = 11[64.7%]）、微褶皱（n = 6[35.3%]）、点状反射率（n = 6[35.3%]）和视网膜褶皱（n = 5[29.4%]）。
AO-SLO成像可详细了解ERM手术后视网膜的微观结构变化。进一步的纵向研究跟踪AO-SLO特征随时间的变化，并整合多模态视网膜成像模式，可能会加深我们对视网膜恢复过程的理解，并改善ERM手术结果的预测。
