Hossain Tania, Hasan Mahamud, Mazumder Ashish K, Momtaz Pilu, Sufian Abu, Khandaker Jabedul Alam, Akhteruzzaman Sharif
National Forensic DNA Profiling Laboratory, Dhaka Medical College, Dhaka 1000, Bangladesh.
Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka 1000, Bangladesh.
Leg Med (Tokyo). 2016 Nov;23:44-46. doi: 10.1016/j.legalmed.2016.09.005. Epub 2016 Sep 15.
Genetic polymorphism of 22 autosomal STR loci included in PowerPlex® Fusion System (D3S1358, D1S1656, D2S441, D10S1248, D13S317, Penta E, D16S539, D18S51, D2S1338, CSF1PO, Penta D, TH01, vWA, D21S11, D7S820, D5S818, TPOX, D8S1179, D12S391, D19S433, FGA and D22S1045) was studied in 188 unrelated Bangladeshi Bengali individuals. Allele frequencies and forensic efficiency parameters such as, the power of discrimination (PD), observed and expected heterozygosity (Ho & He), polymorphism information content (PIC), probability of match (PM), power of exclusion (PE) and typical paternity index was calculated for the loci. The combined PM and PE for all 22 STR loci were calculated to be 5.29×10 and 0.99999999945 respectively. The dataset indicated the usefulness of these loci in personal identification, parentage testing and complex kinship analysis in Bangladeshi population. A neighbor-joining tree was constructed based on pair-wise Nei's genetic distance by comparing allele frequency data for the 22 loci with six other populations. The analysis showed that Bangladeshi population lies closer to a clade consisting Japan, the Philippines and East Timot populations.
在188名不相关的孟加拉国孟加拉族个体中，研究了PowerPlex® Fusion系统中包含的22个常染色体STR基因座（D3S1358、D1S1656、D2S441、D10S1248、D13S317、五核苷酸E、D16S539、D18S51、D2S1338、CSF1PO、五核苷酸D、TH01、vWA、D21S11、D7S820、D5S818、TPOX、D8S1179、D12S391、D19S433、FGA和D22S1045）的基因多态性。计算了这些基因座的等位基因频率和法医效率参数，如鉴别力（PD）、观察到的和预期的杂合度（Ho和He）、多态性信息含量（PIC）、匹配概率（PM）、排除力（PE）和典型父权指数。计算得出所有22个STR基因座的组合PM和PE分别为5.29×10和0.99999999945。该数据集表明这些基因座在孟加拉国人群的个人识别、亲子鉴定和复杂亲属关系分析中有用。通过将22个基因座的等位基因频率数据与其他六个群体进行比较，基于成对的Nei遗传距离构建了邻接树。分析表明，孟加拉国人群更接近一个由日本、菲律宾和东帝汶人群组成的进化枝。
