双氯芬酸对白细胞介素-1刺激的人滑膜成纤维细胞产生前列腺素E和透明质酸的影响。
Effect of diclofenac on prostaglandin E and hyaluronic acid production by human synovial fibroblasts stimulated with interleukin-1.
作者信息
Meyer F A, Yaron I, Mashiah V, Yaron M
机构信息
Department of Rheumatology, Ichilov Hospital, Tel Aviv, Israel.
出版信息
Br J Clin Pharmacol. 1989 Aug;28(2):193-6. doi: 10.1111/j.1365-2125.1989.tb05416.x.
Abstract
Cultured human synovial fibroblasts were stimulated with human recombinant interleukin 1 beta to overproduce prostaglandin E (PGE) and hyaluronic acid (HA). Diclofenac, indomethacin and hydrocortisone inhibited stimulation of PGE production. Half-maximal inhibition occurred at 1.10 x 10(-9), 2.79 x 10(-8) and at 5.52 x 10(-8) M, respectively. Diclofenac or indomethacin had no effect on HA production, while hydrocortisone had an inhibitory effect (half-maximal inhibition at 2.76 x 10(-7) M). This model could be a useful in vitro indicator for the in vivo pharmacological actions of anti-inflammatory drugs.
摘要
用人重组白细胞介素1β刺激培养的人滑膜成纤维细胞，使其过量产生前列腺素E（PGE）和透明质酸（HA）。双氯芬酸、吲哚美辛和氢化可的松抑制PGE的产生。半数最大抑制浓度分别为1.10×10⁻⁹、2.79×10⁻⁸和5.52×10⁻⁸M。双氯芬酸或吲哚美辛对HA的产生没有影响，而氢化可的松有抑制作用（半数最大抑制浓度为2.76×10⁻⁷M）。该模型可能是一种用于评估抗炎药体内药理作用的有用体外指标。
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