Microbiology Division, HiMedia Laboratories Pvt Ltd, Mumbai, Maharashtra, India.
Mumbai, India.
Biochem Pharmacol. 2017 Jun 15;134:35-41. doi: 10.1016/j.bcp.2016.11.021. Epub 2016 Nov 24.
The discovery of antibiotics heralded an era of improved health care. However, the over-prescription and misuse of antibiotics resulted in the development of resistant strains of various pathogens. Since then, there has been an incessant search for discovering novel compounds from bacteria at various locations with extreme conditions. The soil is one of the most explored locations for bioprospecting. In recent times, hypersaline environments and symbiotic associations have been investigated for novel antimicrobial compounds. Among the extreme environments, hot springs are comparatively less explored. Many researchers have reported the presence of microbial life and secretion of antimicrobial compounds by microorganisms in hot springs. A pioneering research in the corresponding author's laboratory resulted in the identification of the antibiotic Fusaricidin B isolated from a hot spring derived eubacteria, Paenibacillus polymyxa, which has been assigned a new application for its anti-tubercular properties. The corresponding author has also reported anti-MRSA and anti-VRE activity of 73 bacterial isolates from hot springs in India.
抗生素的发现开创了改善医疗保健的时代。然而，抗生素的过度处方和滥用导致了各种病原体耐药菌株的出现。从那时起，人们一直在不断地从各种极端环境下的细菌中发现新的化合物。土壤是生物勘探最常探索的地点之一。最近，人们研究了高盐环境和共生关系，以寻找新的抗菌化合物。在极端环境中，温泉的研究相对较少。许多研究人员已经报道了微生物在温泉中存在并分泌抗菌化合物。相应作者实验室的一项开创性研究从温泉衍生的真细菌芽孢杆菌属（Paenibacillus polymyxa）中鉴定出了抗生素 Fusaricidin B，该抗生素因其抗结核特性而被赋予了新的应用。相应的作者还报告了印度温泉中 73 株细菌分离株的抗 MRSA 和抗 VRE 活性。
