Mennin Douglas S, Fresco David M
Hunter College, City University of New York.
Kent State University.
Clin Psychol (New York). 2013 Sep;20(3):258-267. doi: 10.1111/cpsp.12038. Epub 2013 Sep 16.
Rumination, worry, and other forms of negative self-referential processing (NSRP) are familiar to everyone, as reflecting on the self is perhaps our most human characteristic. However, for a substantial subgroup of patients, NSRP arises in response to intense emotionality, worsening the clinical presentation, and diminishing the treatment response. The combination of emotionality and NSRP likely reflects an endophenotype of complicated and treatment refractory patients who fail to achieve a satisfactory treatment response in our trials and our clinics. An important next step is to personalize treatments by deliberately targeting NSRPs within established treatment protocols or in as yet novel treatments. Enriching treatments with mindfulness meditation is one possible avenue for personalized care of patients with this hypothesized endophenotype.
反刍、担忧和其他形式的消极自我参照加工（NSRP）对每个人来说都不陌生，因为反思自我或许是我们最具人性的特征。然而，对于相当一部分患者亚组而言，NSRP是对强烈情绪的反应，会使临床表现恶化，并降低治疗反应。情绪与NSRP的结合可能反映了复杂且难治性患者的一种内表型，这些患者在我们的试验和临床中未能获得令人满意的治疗反应。重要的下一步是通过在既定治疗方案内或尚未出现的新治疗方法中有针对性地针对NSRP来实现个性化治疗。用正念冥想丰富治疗方法是针对这种假定内表型患者进行个性化护理的一种可能途径。
