Nielsen P A, Ahlburg P, Schnedler H O, Christensen J H
Ugeskr Laeger. 1989 Aug 28;151(35):2204-6.
Forty patients between 20 and 40 years and 39 patients between 60 and 80 years, all unpremedicated, were allocated to induction with propofol or thiopentone. The induction dose of propofol in patients between 60 and 80 years was 65% of the dose in the patients between 20 and 40 years. Administration of the induction dose of propofol was followed by an even decrease in mean arterial blood pressure of approximately 16% in young and in elderly patients. Propofol caused a more pronounced decrease in mean arterial blood pressure than thiopentone, both in young and elderly patients.
40名年龄在20至40岁之间且未进行术前用药的患者以及39名年龄在60至80岁之间且未进行术前用药的患者被分配接受丙泊酚或硫喷妥钠诱导麻醉。60至80岁患者的丙泊酚诱导剂量为20至40岁患者剂量的65%。给予丙泊酚诱导剂量后，年轻患者和老年患者的平均动脉血压均均匀下降约16%。在年轻患者和老年患者中，丙泊酚引起的平均动脉血压下降比硫喷妥钠更明显。
