Shen Te-Chun, Hang Liang-Wen, Liang Shinn-Jye, Huang Chien-Chung, Lin Cheng-Li, Tu Chih-Yen, Hsia Te-Chun, Shih Chuen-Ming, Hsu Wu-Huei, Sung Fung-Chang
Graduate Institute of Clinical Medicine Science, College of Medicine, China Medical University, Taichung, Taiwan.
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan.
BMJ Open. 2016 Nov 28;6(11):e013151. doi: 10.1136/bmjopen-2016-013151.
Sleep disorders are prevalent medical disorders in patients with rheumatoid arthritis (RA). However, whether patients with RA are at an increased risk of developing obstructive sleep apnoea (OSA) is unclear.
Using population-based retrospective cohort study to examine the risk of OSA in patients with RA.
We used claims data of the National Health Insurance Research Database (NHIRD) of Taiwan.
We identified a RA cohort with 33 418 patients newly diagnosed in 2000-2010 and a randomly selected non-RA comparison cohort with 33 418 individuals frequency matched by sex, age and diagnosis year.
Incident OSA was estimated by the end of 2011. The HRs of OSA were calculated using the Cox proportional hazards regression analysis.
The overall incidence rate of OSA was 75% greater in the RA cohort than in the non-RA cohort (3.04 vs 1.73/10 000 person-years, p<0.001), with an adjusted HR (aHR) of 1.75 (95% CI 1.18 to 2.60). Stratified analyses by sex, age group and comorbidity revealed that the incidence rates of OSA associated with RA were higher in all subgroups.
This population-based retrospective cohort study suggested that patients with RA should be monitored for the risk of developing OSA.
睡眠障碍在类风湿关节炎（RA）患者中是常见的医学病症。然而，RA患者发生阻塞性睡眠呼吸暂停（OSA）的风险是否增加尚不清楚。
采用基于人群的回顾性队列研究来检查RA患者发生OSA的风险。
我们使用了台湾国民健康保险研究数据库（NHIRD）的理赔数据。
我们确定了一个在2000 - 2010年新诊断出的33418例患者的RA队列，以及一个按性别、年龄和诊断年份频率匹配的随机选择的33418例个体的非RA对照队列。
到2011年底估计新发OSA情况。使用Cox比例风险回归分析计算OSA的风险比（HRs）。
RA队列中OSA的总体发病率比非RA队列高75%（3.04对1.73/10000人年，p<0.001），调整后的HR（aHR）为1.75（95%CI 1.18至2.60）。按性别、年龄组和合并症进行分层分析显示，与RA相关的OSA发病率在所有亚组中均较高。
这项基于人群的回顾性队列研究表明，应监测RA患者发生OSA的风险。
