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本文引用的文献

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Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis.KLF5和Fli1的同时下调是系统性硬化症的一个关键特征。
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Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.转录因子Cdx2缺失时肠道干细胞向胃干细胞的转化
Nat Commun. 2014 Dec 11;5:5728. doi: 10.1038/ncomms6728.
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Immunocompetent mouse models to evaluate intrahepatic T cell responses to HCV vaccines.用于评估肝内T细胞对丙型肝炎病毒疫苗反应的免疫活性小鼠模型。
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The Hippo pathway as a target of the Drosophila DRE/DREF transcriptional regulatory pathway.作为果蝇DRE/DREF转录调控途径靶点的Hippo信号通路
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Berberine activates thermogenesis in white and brown adipose tissue.小檗碱激活白色和棕色脂肪组织的产热作用。
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6
Hippocampal and behavioral dysfunctions in a mouse model of environmental stress: normalization by agomelatine.环境应激小鼠模型中海马和行为功能障碍:阿戈美拉汀的改善作用。
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Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.PHD3的缺失使肿瘤能够克服缺氧生长抑制,并通过表皮生长因子受体(EGFR)维持增殖。
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Ablation of Tak1 in osteoclast progenitor leads to defects in skeletal growth and bone remodeling in mice.破骨细胞祖细胞中Tak1的缺失导致小鼠骨骼生长和骨重塑缺陷。
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Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons.VEGF/SphK信号通路在尼曼-匹克C型神经元中的病理作用
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Journals unite for reproducibility.期刊为可重复性而联合。
Science. 2014 Nov 7;346(6210):679. doi: 10.1126/science.aaa1724.

生物医学研究的可重复性:沉睡者醒来!

The reproducibility of biomedical research: Sleepers awake!

作者信息

Bustin Stephen A

机构信息

Faculty of Medical Science, Postgraduate Medical Institute, Anglia Ruskin University, Chelmsford CM1 1SQ, UK.

出版信息

Biomol Detect Quantif. 2015 Jan 21;2:35-42. doi: 10.1016/j.bdq.2015.01.002. eCollection 2014 Dec.

DOI:10.1016/j.bdq.2015.01.002
PMID:27896142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5121206/
Abstract

There is increasing concern about the reliability of biomedical research, with recent articles suggesting that up to 85% of research funding is wasted. This article argues that an important reason for this is the inappropriate use of molecular techniques, particularly in the field of RNA biomarkers, coupled with a tendency to exaggerate the importance of research findings.

摘要

人们越来越关注生物医学研究的可靠性,最近的文章表明,高达85%的研究资金被浪费了。本文认为,造成这种情况的一个重要原因是分子技术的不当使用,特别是在RNA生物标志物领域,再加上夸大研究结果重要性的倾向。