McCormick P C, Post K D, Kandji A D, Hays A P
Department of Neurological Surgery, Columbia Presbyterian Hospital, New York.
Br J Neurosurg. 1989;3(1):71-9. doi: 10.3109/02688698909001028.
Four patients with metastatic carcinoma to the pituitary gland are presented. Two of these patients had no previous history of malignancy and, based on clinical, laboratory, and radiological evaluation, a preoperative diagnosis of pituitary adenoma was made. In one patient, the histological diagnosis of two consecutive tumour specimens, obtained 1 year apart, was pituitary adenoma. The correct diagnosis of metastatic renal-cell carcinoma was not ascertained until autopsy. In the second patient, a diffusely infiltrating breast carcinoma was diagnosed by mammography and confirmed by biopsy, after pathological examination of the sellar tumour revealed carcinoma. The third patient underwent mastectomy 3 years earlier for breast carcinoma and had known metastatic disease. The fourth patient had known metastatic endometrial carcinoma when she became symptomatic from a pituitary metastasis. The incidence, clinical features, and pathophysiology of metastatic carcinoma to the pituitary gland are discussed.
本文报告了4例垂体转移癌患者。其中2例患者既往无恶性肿瘤病史，根据临床、实验室及影像学评估，术前诊断为垂体腺瘤。1例患者相隔1年获取的两份连续肿瘤标本的组织学诊断均为垂体腺瘤。直至尸检才确诊为转移性肾细胞癌。第2例患者经乳房X线摄影诊断为弥漫浸润性乳腺癌，蝶鞍肿瘤病理检查显示为癌后经活检确诊。第3例患者3年前因乳腺癌接受乳房切除术，已知有转移病灶。第4例患者因垂体转移出现症状时已确诊有转移性子宫内膜癌。本文还讨论了垂体转移癌的发病率、临床特征及病理生理学。
