Tianjin Central Hospital of Gynecology Obstetrics, No. 156 Nankai Sanma Road Nankai District, Tianjin 300100, PR China.
Tianjin Medical University, 22 Qixiangtai Road, Tianjin 300070, PR China.
Sci Rep. 2016 Nov 29;6:38047. doi: 10.1038/srep38047.
The long noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR) is associated with the development and progression of several types of cancer; however, its role in cervical cancer is unclear. Here, we performed a meta-analysis to evaluate the expression levels and clinical significance of HOTAIR in cervical cancer tissue. Relevant literature published by January 2016 was identified in PubMed, EMBase, National Knowledge Infrastructure, Wanfang Database, and Chinese Biomedical Literature Database. We performed statistical analysis, calculated standard mean differences (SMDs), and determined combined odds ratios (ORs) with 95% confidence intervals. A forest map was constructed. From the literature search, six papers (reporting 535 cases) were included from 578 papers selected according to the inclusion criteria established for the meta-analysis. The analysis showed that HOTAIR expression was significantly increased in cervical cancer compared with that in the normal control group. The ORs for tumour size and lymph node metastasis in patients with cervical cancer having high HOTAIR expression were 2.20 and 7.52, respectively. The combined hazard ratio, reflecting the influence of high HOTAIR expression in patients with cervical cancer on overall survival, was 2.56. High expression of HOTAIR affected the occurrence and development of cervical cancer.
长链非编码 RNA HOX 转录反义基因间 RNA（HOTAIR）与多种类型癌症的发生和发展有关；然而，其在宫颈癌中的作用尚不清楚。本研究进行了一项荟萃分析，以评估 HOTAIR 在宫颈癌组织中的表达水平及其临床意义。通过 PubMed、EMBase、中国知网、万方数据库和中国生物医学文献数据库检索了截至 2016 年 1 月发表的相关文献。我们进行了统计学分析，计算了标准均数差（SMD），并确定了合并优势比（OR）及其 95%置信区间。绘制了森林图。根据纳入荟萃分析的标准筛选出 578 篇文献，最终有 6 篇文献（报告了 535 例）符合纳入标准，被纳入研究。分析结果表明，与正常对照组相比，宫颈癌组织中 HOTAIR 的表达明显升高。HOTAIR 高表达的宫颈癌患者肿瘤大小和淋巴结转移的 OR 分别为 2.20 和 7.52。反映 HOTAIR 高表达对宫颈癌患者总生存影响的合并危险比为 2.56。HOTAIR 的高表达影响了宫颈癌的发生和发展。
