Miyaki Asako, Maeda Seiji, Yoshizawa Mutsuko, Misono Maiko, Saito Yoko, Sasai Hiroyuki, Kim Maeng-Kyu, Nakata Yoshio, Tanaka Kiyoji, Ajisaka Ryuichi
Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Am J Cardiol. 2009 Sep 15;104(6):823-8. doi: 10.1016/j.amjcard.2009.04.057.
The effect of habitual exercise on vascular function, including central arterial distensibility and endothelial function, in obese subjects has not yet been clarified. We investigated whether aerobic exercise training affects central arterial distensibility and endothelial function in middle-age overweight and obese men. A total of 21 overweight and obese men (age 50 +/- 2 years, body mass index 30 +/- 1 kg/m(2)) completed a 12-week aerobic exercise intervention. Aerobic exercise training significantly reduced their body weight and resulted in a significant decrease in body mass index. After the weight-reduction exercise program, carotid arterial compliance (determined by simultaneous B-mode ultrasonography and arterial applanation tonometry on the common carotid artery) significantly increased; and the beta-stiffness index, an index of arterial compliance adjusted for distending pressure, significantly decreased. The concentrations of plasma endothelin-1, a potent vasoconstrictor peptide produced by vascular endothelial cells, significantly decreased and plasma nitric oxide (measured as the stable end product [nitrite/nitrate]), a potent vasodilator produced by vascular endothelial cells, significantly increased after the weight-reduction exercise program. In conclusion, weight reduction by aerobic exercise training in overweight and obese men increased the central arterial distensibility. This increase might contribute to the improvement in endothelial function, as assessed by a decrease in endothelin-1 and an increase in nitric oxide, after exercise training-induced weight loss.
习惯性运动对肥胖受试者血管功能（包括中心动脉扩张性和内皮功能）的影响尚未明确。我们研究了有氧运动训练是否会影响中年超重和肥胖男性的中心动脉扩张性及内皮功能。共有21名超重和肥胖男性（年龄50±2岁，体重指数30±1kg/m²）完成了为期12周的有氧运动干预。有氧运动训练显著降低了他们的体重，并使体重指数显著下降。在减重运动计划后，颈动脉顺应性（通过对颈总动脉同时进行B型超声检查和动脉压平式张力测定来确定）显著增加；并且β-硬度指数（一种经扩张压力校正的动脉顺应性指标）显著降低。血管内皮细胞产生的一种强力血管收缩肽——血浆内皮素-1的浓度显著降低，而血管内皮细胞产生的一种强力血管舒张剂——血浆一氧化氮（以稳定终产物[亚硝酸盐/硝酸盐]来衡量）在减重运动计划后显著增加。总之，超重和肥胖男性通过有氧运动训练减重可增加中心动脉扩张性。这种增加可能有助于运动训练引起体重减轻后内皮功能的改善，这可通过内皮素-1的减少和一氧化氮的增加来评估。
