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卡菲利心脏疾病协作研究中的血液粘度与听力水平

Blood viscosity and hearing levels in the Caerphilly Collaborative Heart Disease Study.

作者信息

Gatehouse S, Gallacher J E, Lowe G D, Yarnell J W, Hutton R D, Ising I

机构信息

Medical Research Council Institute of Hearing Research (Scottish Section), Glasgow, Scotland.

出版信息

Arch Otolaryngol Head Neck Surg. 1989 Oct;115(10):1227-30. doi: 10.1001/archotol.1989.01860340081022.

DOI:10.1001/archotol.1989.01860340081022
PMID:2789779
Abstract

Data from 342 men who are participants in the Caerphilly Collaborative Heart Disease Study were used to replicate a previous report of a significant relationship between measures of whole-blood viscosity and hearing levels in persons with sensorineural hearing impairment. In the unselected data, there were significant relationships between measures of whole-blood viscosity at high shear rates and hearing threshold levels at 2000 and 4000 Hz, even after accounting for the effects of age and socioeconomic group. In a subset of the data containing 124 persons selected on the basis of likely sensorineural hearing impairment, there were significant relationships between whole-blood viscosity and hearing level at all frequencies, with stronger effects at the higher frequencies. The data support the contention of a potentially important relationship between whole-blood viscosity and sensorineural hearing impairment.

摘要

来自342名参与卡菲利协作性心脏病研究的男性的数据,被用于复制之前一份关于全血粘度测量值与感音神经性听力损失患者听力水平之间存在显著关系的报告。在未经过筛选的数据中,即使在考虑了年龄和社会经济群体的影响之后,高剪切率下的全血粘度测量值与2000赫兹和4000赫兹时的听力阈值水平之间仍存在显著关系。在基于可能的感音神经性听力损失挑选出的124人的数据子集中,全血粘度与所有频率下的听力水平之间都存在显著关系,在较高频率下影响更强。这些数据支持了全血粘度与感音神经性听力损失之间可能存在重要关系的论点。

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