Lee F S, Matthews L J, Mills J H, Dubno J R, Adkins W Y
Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston 29425-2242, USA.
Ear Hear. 1998 Jun;19(3):180-90. doi: 10.1097/00003446-199806000-00002.
As part of an ongoing study of presbyacusis, the relationship between blood chemistry levels and hearing levels was investigated. Previous reports often used small sets of blood chemistry measures, and results were inconclusive. This experiment examined hearing levels and 27 measures of blood chemistry using various univariate and multivariate statistical procedures.
Blood from 89 female and 128 male human subjects was collected. Subjects' ages ranged from 60 to 82 yr, and hearing levels ranged from normal to moderate/severe. Subjects with a history of middle ear disease were excluded. Electrolyte panel (Na, K, Cl, CO2, Ca, urea nitrogen, glucose, creatinine, and Mg), hematology panel (WBC, RBC, Hgb, hematocrit, platelet, etc.), serum lipids (total cholesterol, low-density lipoprotein [LDL], and high-density lipoprotein [HDL]), immunoglobulins (IgG, IgA, IgM, and IgE), and thyroxine were analyzed using univariate and multivariate statistical procedures.
Blood chemistry levels of most subjects were within normal ranges as defined by our laboratory. Correlation between blood chemistry measures and pure-tone averages (PTAs) ranged from minimal to low. Results of factor analysis, discriminant analysis, and canonical analysis showed that combining blood chemistry measures from the same panel still could not predict PTA effectively. One exception to this was a gender-specific effect of cholesterol. Hearing levels of women with high LDL/HDL ratios were 5 dB better than those of women with low LDL/HDL ratios. The comparable difference in men was only 1 dB.
Results suggest that blood chemistry measures that are primarily within the normal range have very little value in predicting pure-tone thresholds in older subjects.
作为一项正在进行的老年性聋研究的一部分，研究了血液化学水平与听力水平之间的关系。以往的报告往往使用少量的血液化学指标，结果尚无定论。本实验使用各种单变量和多变量统计程序，对听力水平和27项血液化学指标进行了检测。
采集了89名女性和128名男性受试者的血液。受试者年龄在60至82岁之间，听力水平从正常到中度/重度不等。有中耳疾病史的受试者被排除在外。使用单变量和多变量统计程序分析了电解质组（钠、钾、氯、二氧化碳、钙、尿素氮、葡萄糖、肌酐和镁）、血液学组（白细胞、红细胞、血红蛋白、血细胞比容、血小板等）、血脂（总胆固醇、低密度脂蛋白[LDL]和高密度脂蛋白[HDL]）、免疫球蛋白（IgG、IgA、IgM和IgE）以及甲状腺素。
大多数受试者的血液化学水平在我们实验室定义的正常范围内。血液化学指标与纯音平均听阈（PTA）之间的相关性从最小到低不等。因子分析、判别分析和典型相关分析的结果表明，将同一组的血液化学指标组合起来仍然无法有效地预测PTA。唯一的例外是胆固醇的性别特异性效应。低密度脂蛋白/高密度脂蛋白比值高的女性听力水平比比值低的女性好5分贝。男性的可比差异仅为1分贝。
结果表明，主要在正常范围内的血液化学指标在预测老年受试者的纯音阈值方面价值不大。
