Nikkilä M T, Saaristo J J
Department of Clinical Sciences, University of Tampere, Finland.
Ann Med. 1989 Aug;21(4):281-3. doi: 10.3109/07853898909149207.
Forty-nine patients with primary hyperparathyroidism were examined preoperatively and three months after parathyroid operation for their serum vitamin D metabolites and routine laboratory samples related to calcium metabolism. The preoperative serum 24,25-dihydroxyvitamin D level, mean (SE) was 1.86 (0.22) nmol/l and the postoperative level 5.35 (0.63) nmol/l, the difference being highly significant (P less than 0.001). Serum 1,25-dihydroxyvitamin D levels fell significantly (P less than 0.001) from a preoperative level of 175.5 (17.9) pmol/l to 102.8 (10.1) pmol/l postoperatively. The preoperative 25-hydroxyvitamin D level did not change significantly after surgery. The preoperative serum 24,25-dihydroxyvitamin D level was very low, especially in patients with bone disease while serum parathormone was significantly higher than in patients without bone disease.
对49例原发性甲状旁腺功能亢进患者进行了术前检查，并在甲状旁腺手术后3个月检测了他们的血清维生素D代谢产物以及与钙代谢相关的常规实验室样本。术前血清24,25-二羟维生素D水平，均值（标准误）为1.86（0.22）nmol/l，术后水平为5.35（0.63）nmol/l，差异具有高度显著性（P小于0.001）。血清1,25-二羟维生素D水平从术前的175.5（17.9）pmol/l显著下降（P小于0.001）至术后的102.8（10.1）pmol/l。术前25-羟维生素D水平术后无显著变化。术前血清24,25-二羟维生素D水平非常低，尤其是在患有骨病的患者中，而血清甲状旁腺激素明显高于无骨病的患者。
