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XTalkDB：一个信号通路串扰数据库。

XTalkDB: a database of signaling pathway crosstalk.

作者信息

Sam Sarah A, Teel Joelle, Tegge Allison N, Bharadwaj Aditya, Murali T M

机构信息

Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA.

School of Neuroscience, Virginia Tech, Blacksburg, VA 24061, USA.

出版信息

Nucleic Acids Res. 2017 Jan 4;45(D1):D432-D439. doi: 10.1093/nar/gkw1037. Epub 2016 Nov 28.

DOI:10.1093/nar/gkw1037
PMID:27899583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5210533/
Abstract

Analysis of signaling pathways and their crosstalk is a cornerstone of systems biology. Thousands of papers have been published on these topics. Surprisingly, there is no database that carefully and explicitly documents crosstalk between specific pairs of signaling pathways. We have developed XTalkDB (http://www.xtalkdb.org) to fill this very important gap. XTalkDB contains curated information for 650 pairs of pathways from over 1600 publications. In addition, the database reports the molecular components (e.g. proteins, hormones, microRNAs) that mediate crosstalk between a pair of pathways and the species and tissue in which the crosstalk was observed. The XTalkDB website provides an easy-to-use interface for scientists to browse crosstalk information by querying one or more pathways or molecules of interest.

摘要

信号通路及其相互作用的分析是系统生物学的基石。关于这些主题已经发表了数千篇论文。令人惊讶的是，没有一个数据库能仔细且明确地记录特定信号通路对之间的相互作用。我们开发了XTalkDB（http://www.xtalkdb.org）来填补这一非常重要的空白。XTalkDB包含了来自1600多篇出版物的650对通路的精心策划的信息。此外，该数据库还报告了介导一对通路之间相互作用的分子成分（如蛋白质、激素、微小RNA）以及观察到这种相互作用的物种和组织。XTalkDB网站为科学家提供了一个易于使用的界面，通过查询一个或多个感兴趣的通路或分子来浏览相互作用信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa75/5210533/1e83c97a1a53/gkw1037fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa75/5210533/862d174af0a7/gkw1037fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa75/5210533/a45c0b0b1451/gkw1037fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa75/5210533/1e83c97a1a53/gkw1037fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa75/5210533/862d174af0a7/gkw1037fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa75/5210533/a45c0b0b1451/gkw1037fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa75/5210533/1e83c97a1a53/gkw1037fig3.jpg

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