Mann Steven, Jimenez Alfonso, Domone Sarah, Beedie Chris
Faculty of Health and Life Sciences, Centre for Applied Biological and Exercise Sciences, Coventry University, Coventry, UK; ukactive Research Institute, London, UK.
ukactive Research Institute , London , UK.
BMJ Open Sport Exerc Med. 2016 Mar 30;2(1):e000105. doi: 10.1136/bmjsem-2015-000105. eCollection 2016.
Insufficient research examines the treatment effectiveness of real-world physical activity (PA) interventions.
We investigated the effects of 3 interventions on directly measured cardiovascular variables. All treatments and measures were administered in community settings by fitness centre staff.
Participants were sedentary individuals receiving no medication to reduce cardiovascular disease (CVD) risk (n=369, age 43 ±5 years). In a semirandomised design, participants were allocated to a structured gym exercise programme (STRUC), unstructured gym exercise (FREE), physical activity counselling (PAC) or a measurement-only control condition (CONT). Measures were: predicted aerobic capacity (VO: mL kg min), mean arterial blood pressure (MAP: mm Hg) and total cholesterol (TC: mmol/L), and were taken at baseline and 48 weeks.
Data analysis indicated a statistically significant deterioration in TC in CONT (0.8%, SD=0.5, p=0.005), and a statistically significant improvement in MAP in STRUC (2.5%, SD=8.3, p=0.004). Following a median split by baseline VO, paired-sample t tests indicated significant improvements in VO among low-fit participants in STRUC (3.5%, SD=4.8, p=0.003), PAC (3.3%, SD=7.7, p=0.050) and FREE (2.6%, SD=4.8, p=0.006), and significant deterioration of VO among high-fit participants in FREE (-2.0%, SD=5.6, p=0.037), and PAC (-3.2%, SD=6.4, p=0.031).
Several forms of PA may offset increased cholesterol resulting from inactivity. Structured PA (exercise) might be more effective than either unstructured PA or counselling in improving blood pressure, and community-based PA interventions might be more effective in improving VO among low-fit than among high-fit participants.
针对现实世界中体育活动(PA)干预措施的治疗效果,相关研究尚不充分。
我们研究了三种干预措施对直接测量的心血管变量的影响。所有治疗和测量均由健身中心工作人员在社区环境中进行。
参与者为久坐不动且未服用降低心血管疾病(CVD)风险药物的个体(n = 369,年龄43±5岁)。采用半随机设计,将参与者分配到结构化健身房锻炼计划(STRUC)、非结构化健身房锻炼(FREE)、体育活动咨询(PAC)或仅测量的对照条件(CONT)。测量指标包括:预测有氧能力(VO:毫升·千克·分钟)、平均动脉血压(MAP:毫米汞柱)和总胆固醇(TC:毫摩尔/升),并在基线和48周时进行测量。
数据分析表明,CONT组的TC有统计学意义的恶化(0.8%,标准差 = 0.5,p = 0.005),STRUC组的MAP有统计学意义的改善(2.5%,标准差 = 8.3,p = 0.004)。根据基线VO进行中位数分割后,配对样本t检验表明,STRUC组(3.5%,标准差 = 4.8,p = 0.003)、PAC组(3.3%,标准差 = 7.7,p = 0.050)和FREE组(2.6%,标准差 = 4.8,p = 0.006)中低健康水平参与者的VO有显著改善,FREE组(-2.0%,标准差 = 5.6,p = 0.037)和PAC组(-3.2%,标准差 = 6.4,p = 0.031)中高健康水平参与者的VO有显著恶化。
几种形式的体育活动可能抵消因缺乏运动导致的胆固醇升高。结构化体育活动(锻炼)在改善血压方面可能比非结构化体育活动或咨询更有效,基于社区的体育活动干预在改善低健康水平参与者的VO方面可能比高健康水平参与者更有效。