近亲繁殖对智商和智力迟钝的影响。
Effect of inbreeding on IQ and mental retardation.
作者信息
Morton N E
出版信息
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3906-8. doi: 10.1073/pnas.75.8.3906.
Abstract
Both decline of IQ and increase of mental retardation are consistent with rare recessive alleles at about 325 loci. There is no suggestion of a discrepancy that might be due to polygenic dominance or confounding of consanguinity with unfavorable environment. These data indicate that the risk for mental retardation in matings of normal parents increases from 0.012 with random mating to 0.062 for first-cousin parentage but that dominance deviations are a negligible cause of family resemblance of IQ. Implications for frequencies, mutation rates, and radiation response are detailed.
摘要
智商下降和智力迟钝增加都与约325个基因座上的罕见隐性等位基因一致。没有迹象表明存在可能归因于多基因显性或近亲结婚与不利环境混淆的差异。这些数据表明，正常父母交配时智力迟钝的风险从随机交配的0.012增加到表亲结婚的0.062，但显性偏差是智商家族相似性的一个可忽略不计的原因。详细说明了对频率、突变率和辐射反应的影响。
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