Physikalisches Institut and Center for Nanotechnology, Westfälische Wilhelms-Universität Münster, Heisenbergstrasse 11, D-48149, Münster, Germany.
Adv Healthc Mater. 2017 Jan;6(1). doi: 10.1002/adhm.201600938. Epub 2016 Nov 30.
Nanocomposite (NC) hydrogels, organic-inorganic hybrid materials, are of great interest as artificial three-dimensional (3D) biomaterials for biomedical applications. NC hydrogels are prepared in water by chemically or physically cross-linking organic polymers with nanomaterials (NMs). The incorporation of hard inorganic NMs into the soft organic polymer matrix enhances the physical, chemical, and biological properties of NC hydrogels. Therefore, NC hydrogels are excellent candidates for artificial 3D biomaterials, particularly in tissue engineering applications, where they can mimic the chemical, mechanical, electrical, and biological properties of native tissues. A wide range of functional NMs and synthetic or natural organic polymers have been used to design new NC hydrogels with novel properties and tailored functionalities for biomedical uses. Each of these approaches can improve the development of NC hydrogels and, thus, provide advanced 3D biomaterials for biomedical applications.
纳米复合（NC）水凝胶是一种有机-无机杂化材料，作为用于生物医学应用的人工三维（3D）生物材料备受关注。NC 水凝胶是通过将纳米材料（NMs）与有机聚合物化学或物理交联在水中制备的。将硬无机 NMs 掺入软有机聚合物基质中可增强 NC 水凝胶的物理、化学和生物学特性。因此，NC 水凝胶是人工 3D 生物材料的理想候选材料，特别是在组织工程应用中，它们可以模拟天然组织的化学、机械、电气和生物学特性。为了设计具有新型特性和针对生物医学用途的定制功能的新型 NC 水凝胶，已经使用了广泛的功能 NMs 和合成或天然有机聚合物。这些方法中的每一种都可以改进 NC 水凝胶的开发，从而为生物医学应用提供先进的 3D 生物材料。
