Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854. United States.
Institute of Chemistry, University of Sao Paulo (USP), CP 26077, CEP 05513-970, Sao Paulo. Brazil.
Curr Pharm Des. 2017;23(26):3794-3813. doi: 10.2174/1381612823666170710160615.
This review article provides an overview of hybrid and nanocomposite materials used as biomaterials in nanomedicine, focusing on applications in controlled drug delivery, tissue engineering, biosensors and theranostic systems. Special emphasis is placed on the importance of tuning the properties of nanocomposites, which can be achieved by choosing appropriate synthetic methods and seeking synergy among different types of materials, particularly exploiting their nanoscale nature. The challenges in fabrication for the nanocomposites are highlighted by classifying them as those comprising solely inorganic phases (inorganic/inorganic hybrids), organic phases (organic/organic hybrids) and both types of phases (organic/inorganic hybrids). A variety of examples are given for applications from the recent literature, from which one may infer that significant developments for effective use of hybrid materials require a delicate balance among structure, biocompatibility, and stability.
这篇综述文章概述了用于纳米医学的生物材料中的混合和纳米复合材料，重点介绍了在控制药物输送、组织工程、生物传感器和治疗诊断系统中的应用。特别强调了调整纳米复合材料性能的重要性，这可以通过选择合适的合成方法和寻求不同类型材料之间的协同作用来实现，特别是利用它们的纳米级性质。通过将纳米复合材料分为仅包含无机相（无机/无机杂化）、有机相（有机/有机杂化）和两种类型的相（有机/无机杂化），突出了它们在制造方面的挑战。从最近的文献中给出了各种应用的例子，从中可以推断出，为了有效利用混合材料，需要在结构、生物相容性和稳定性之间取得微妙的平衡。
