Moss H B, Yao J K, Panzak G L
Department of Psychiatry, University of Pittsburgh School of Medicine.
Biol Psychiatry. 1990 Aug 15;28(4):325-38. doi: 10.1016/0006-3223(90)90660-t.
In order to assess the possibility of altered serotonergic responsivity in antisocial personality disorder with substance abuse (ASP), 15 men with ASP and 12 controls were challenged with the serotonin agonist, m-chlorophenylpiperazine (m-CPP), and prolactin and cortisol responses were evaluated. Psychometric measures of hostility and aggression, impulsivity, cognitive tempo, and various aspects of sociopathy were also obtained. ASP subjects had a significantly reduced prolactin response to m-CPP compared with controls, and a significantly greater cortisol response. The prolactin responses showed a significant inverse correlation with measures of assaultive aggression, hypophoria (negative affects), and increased needs. There was no significant correlation found between cortisol responses and any of the psychometric measures. Impulsivity as characterized either by behavioral self-report or measurement of cognitive tempo did not correlate with either prolactin or cortisol responses. A discriminant function analysis depicted ASP subjects as displaying resentment towards others and having poor test-taking efficiency, heightened irritability, and diminished prolactin response to m-CPP. Using these four criteria, nearly 93% of subjects were successfully classified. These results suggest that altered serotonergic function is associated with assaultiveness and dysphoria but not impulsivity in individuals with ASP.
为了评估伴有物质滥用的反社会人格障碍（ASP）患者血清素反应性改变的可能性，对15名患有ASP的男性和12名对照者给予血清素激动剂间氯苯哌嗪（m-CPP）进行激发试验，并评估催乳素和皮质醇反应。同时还获取了敌意和攻击性、冲动性、认知速度以及反社会行为各方面的心理测量指标。与对照组相比，ASP患者对m-CPP的催乳素反应显著降低，而皮质醇反应显著增强。催乳素反应与攻击性侵犯、情绪低落（消极情绪）以及需求增加的测量指标呈显著负相关。未发现皮质醇反应与任何心理测量指标之间存在显著相关性。通过行为自我报告或认知速度测量所表征的冲动性与催乳素或皮质醇反应均无相关性。判别函数分析显示，ASP患者表现出对他人的怨恨、考试效率低下、易怒性增强以及对m-CPP的催乳素反应减弱。使用这四个标准，近93%的受试者被成功分类。这些结果表明，血清素功能改变与ASP患者的攻击性和烦躁不安有关，但与冲动性无关。
