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利用人群水平调查和关联的医疗保健管理数据评估慢性疼痛患者的健康效用值

Health utilities in people with chronic pain using a population-level survey and linked health care administrative data.

作者信息

Hogan Mary-Ellen, Taddio Anna, Katz Joel, Shah Vibhuti, Krahn Murray

机构信息

Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.

出版信息

Pain. 2017 Mar;158(3):408-416. doi: 10.1097/j.pain.0000000000000776.

Abstract

Health utilities are a preference-based measure of health-related quality of life that facilitates comparison of disease burden across conditions. We estimated utilities using a population-based, matched sample of adolescents and adults with and without chronic pain, controlling for comorbidity. Ontarians aged ≥12 years with and without chronic pain were identified from the Canadian Community Health Survey (CCHS) 2000-2001 and 2009-2010 and linked to their provincial health care administrative data. Individuals with chronic pain were matched to those without using age, sex, survey year, and a propensity score for having chronic pain estimated from a rurality index, income quintile, and comorbidity. The Health Utilities Index Mark 3 instrument, included in the Canadian Community Health Survey, was used. Mean utilities were calculated for each group. Utility decrement for chronic pain was also calculated for each matched pair. A total of 65,246 responses were available for analysis. After matching, there were 12,146 matched pairs with and without pain. In the matched cohort, mean age was 54 years (SD 12); 61% were female. The matched cohort with chronic pain had a mean utility of 0.59 (95% confidence interval 0.58-0.59), and the decrement associated with chronic pain was 0.32 (95% confidence interval 0.31-0.32). Utilities in people with chronic pain were lower than, and decrements larger than, those seen with most other chronic diseases including heart disease, diabetes, and chronic obstructive pulmonary disease. These data will be useful to inform priorities and future strategies for the prevention and control of chronic pain.

摘要

健康效用是一种基于偏好的健康相关生活质量衡量指标,有助于比较不同疾病的负担。我们使用基于人群的、匹配的青少年和成人样本(包括有和没有慢性疼痛的人群)来估计效用,并对合并症进行了控制。通过2000 - 2001年和2009 - 2010年的加拿大社区健康调查(CCHS),识别出安大略省年龄≥12岁且有和没有慢性疼痛的人群,并将其与省级医疗保健管理数据相链接。患有慢性疼痛的个体与未患慢性疼痛的个体按照年龄、性别、调查年份以及根据农村指数、收入五分位数和合并症估计的患慢性疼痛倾向得分进行匹配。使用了加拿大社区健康调查中包含的健康效用指数Mark 3工具。计算了每组的平均效用。还为每对匹配个体计算了慢性疼痛导致的效用递减。共有65,246份回复可供分析。匹配后,有12,146对有疼痛和无疼痛的匹配个体。在匹配队列中,平均年龄为54岁(标准差12);61%为女性。患有慢性疼痛的匹配队列的平均效用为0.59(95%置信区间0.58 - 0.59),与慢性疼痛相关的效用递减为0.32(95%置信区间0.31 - 0.32)。慢性疼痛患者的效用低于包括心脏病、糖尿病和慢性阻塞性肺疾病在内的大多数其他慢性疾病患者,且效用递减幅度更大。这些数据将有助于为慢性疼痛的预防和控制确定优先事项及未来策略提供参考。

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