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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Chequer-Bou-Habib D, Oliveira-Neto M P, Ferreira-da-Cruz M F, Galvão-Castro B

Departamento de Imunologia, WHO Collaborating Centre for Research and Training in the Immunology of Parasitic Disease, Rio de Janeiro, Brasil.

Braz J Med Biol Res. 1989;22(2):205-12.

The nature and extent of immune abnormalities was studied in 28 untreated patients with a chronic moderate form of paracoccidioidomycosis (PCM). 2. The patients presented hyporeactivity to skin tests, diminished lymphocyte transformation by mitogens such as phytohemagglutinin-P and concanavalin A and by Paracoccidioides brasiliensis protein antigen. They also presented peripheral blood leukocytosis but normal absolute numbers of T-cell and T-cell subsets. 3. The patients had increased serum levels of C3d, as well as high levels of circulating immune complexes (CIC) detected by C1q-binding and protein A-binding assays. 4. There was a significant negative correlation between lymphocyte transformation by mitogens and CIC levels which suggested that CIC may be involved in the genesis of the depressed cell-mediated immunity in PCM patients.

对28例未经治疗的慢性中度副球孢子菌病（PCM）患者的免疫异常性质和程度进行了研究。2. 这些患者对皮肤试验反应低下，对诸如植物血凝素-P和刀豆球蛋白A等有丝分裂原以及巴西副球孢子菌蛋白抗原的淋巴细胞转化能力降低。他们还出现外周血白细胞增多，但T细胞及其亚群的绝对数量正常。3. 患者血清C3d水平升高，通过C1q结合试验和蛋白A结合试验检测到高水平的循环免疫复合物（CIC）。4. 有丝分裂原诱导的淋巴细胞转化与CIC水平之间存在显著负相关，这表明CIC可能参与了PCM患者细胞介导免疫抑制的发生。

Chequer-Bou-Habib D, Oliveira-Neto M P, Ferreira-da-Cruz M F, Galvão-Castro B

Departamento de Imunologia, WHO Collaborating Centre for Research and Training in the Immunology of Parasitic Disease, Rio de Janeiro, Brasil.

Braz J Med Biol Res. 1989;22(2):205-12.

The nature and extent of immune abnormalities was studied in 28 untreated patients with a chronic moderate form of paracoccidioidomycosis (PCM). 2. The patients presented hyporeactivity to skin tests, diminished lymphocyte transformation by mitogens such as phytohemagglutinin-P and concanavalin A and by Paracoccidioides brasiliensis protein antigen. They also presented peripheral blood leukocytosis but normal absolute numbers of T-cell and T-cell subsets. 3. The patients had increased serum levels of C3d, as well as high levels of circulating immune complexes (CIC) detected by C1q-binding and protein A-binding assays. 4. There was a significant negative correlation between lymphocyte transformation by mitogens and CIC levels which suggested that CIC may be involved in the genesis of the depressed cell-mediated immunity in PCM patients.

对28例未经治疗的慢性中度副球孢子菌病（PCM）患者的免疫异常性质和程度进行了研究。2. 这些患者对皮肤试验反应低下，对诸如植物血凝素-P和刀豆球蛋白A等有丝分裂原以及巴西副球孢子菌蛋白抗原的淋巴细胞转化能力降低。他们还出现外周血白细胞增多，但T细胞及其亚群的绝对数量正常。3. 患者血清C3d水平升高，通过C1q结合试验和蛋白A结合试验检测到高水平的循环免疫复合物（CIC）。4. 有丝分裂原诱导的淋巴细胞转化与CIC水平之间存在显著负相关，这表明CIC可能参与了PCM患者细胞介导免疫抑制的发生。