Restrepo A, Restrepo M, de Restrepo F, Aristizábal L H, Moncada L H, Vélez H
Sabouraudia. 1978 Jun;16(2):151-63.
Serum electrophoresis patterns and various measures of specific and non-specific immune competence were determined in 16 patients with paracoccidioidomycosis, at time of diagnosis and 6 months after therapy. The results were compared with those furnished by the study of 16 control subjects, matched by age and sex. Once treated, the patients approached normality in some parameters. Untreated patients had significantly diminished albumin levels with increased alpha 1, alpha 2 and gamma fractions. Immune gamma globulin G (IgG) was elevated and remained so during therapy. Both before and after treatment patients had diminished total numbers and decreased percentages of E rosettes; they also had depressed lymphocyte transformation with phytohemagglutinin (PHA) and paracoccidioidin (P). Also, untreated patients exhibited the lowest skin test responses to PHA, purified protein derivative (PPD), P and candidin (C); significant differences, however, were limited to the former 2 antigens. All untreated patients had detectable antibody titers against P. brasiliensis; these titers had a tendency to drop during treatment. No direct correlation was found between elevated serum fractions, presence of antibodies and depressed cellular immunity.
对16例副球孢子菌病患者在诊断时和治疗6个月后进行了血清电泳图谱以及特异性和非特异性免疫能力的各项测定。将结果与16名年龄和性别相匹配的对照受试者的研究结果进行了比较。一旦接受治疗，患者的某些参数接近正常。未经治疗的患者白蛋白水平显著降低，α1、α2和γ组分增加。免疫球蛋白G（IgG）升高且在治疗期间一直如此。治疗前后患者的E玫瑰花结总数和百分比均降低；他们对植物血凝素（PHA）和副球孢子菌素（P）的淋巴细胞转化也受到抑制。此外，未经治疗的患者对PHA、纯化蛋白衍生物（PPD）、P和念珠菌素（C）的皮肤试验反应最低；然而，显著差异仅限于前两种抗原。所有未经治疗的患者均检测到针对巴西副球孢子菌的抗体滴度；这些滴度在治疗期间有下降趋势。血清组分升高、抗体存在与细胞免疫抑制之间未发现直接相关性。
