Chequer-Bou-Habib D, Daniel-Ribeiro C, Banic D M, do Valle A C, Galvao-Castro B
Departamento de Imunologia, WHO Collaborating Centre for Research and Training in the Immunology of Parasitic Diseases, Rio de Janeiro, Brazil.
Mycopathologia. 1989 Nov;108(2):89-93. doi: 10.1007/BF00436058.
Paracoccidioidomycosis (PCM) is often associated with hypergammaglobulinemia and increased serum levels of circulating immune complexes (CIC). In order to investigate whether polyclonal B lymphocyte activation (PBA) is a current process in PCM, we measured the numbers of IgG secreting cells (IgG SC) in the peripheral blood of 16 patients and of 8 healthy controls. The numbers of IgG SC were found to be significantly elevated in PCM patients. We also observed increased serum levels of IgG, IgA and CIC. These data reflect an activation of B lymphocytes in PCM patients.
副球孢子菌病（PCM）常与高球蛋白血症及循环免疫复合物（CIC）血清水平升高相关。为了研究多克隆B淋巴细胞激活（PBA）在PCM中是否为当前存在的过程，我们检测了16例患者及8名健康对照者外周血中分泌IgG的细胞（IgG SC）数量。结果发现PCM患者的IgG SC数量显著升高。我们还观察到患者血清中IgG、IgA及CIC水平升高。这些数据反映了PCM患者B淋巴细胞的激活。
