Department of Chemistry and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Carrer dels Til.lers, UAB Campus, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
Molecules. 2020 Jul 17;25(14):3264. doi: 10.3390/molecules25143264.
In this review, recent advances over the past decade in the preparation of fluorinated stereogenic quaternary centers on -keto esters compounds are analyzed. Since the incorporation of fluorine and fluorinated groups is of special interest in pharmaceutical chemistry, a range of metal-catalyzed and organocatalyzed methods have been developed. Herein, we review the enantioselective fluorination, trifluoromethylation and trifluoromethylthiolation of 3-oxo esters. The scope, the induction of enantioselectivity and mechanistic investigations are presented.
在这篇综述中，分析了过去十年中在制备氟代手性季碳中心的 - 酮酯化合物方面的最新进展。由于氟和氟代基团的引入在药物化学中具有特殊的意义，因此已经开发了一系列金属催化和有机催化方法。本文综述了 3-氧代酯的对映选择性氟化、三氟甲基化和三氟甲硫基化。介绍了反应的范围、对映选择性的诱导和机理研究。
