Zhou Jun-Feng, Wang Yi-Guo, Cheng Liang, Wu Zhao, Sun Xiao-Dan, Peng Jiang
Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing, China.
Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China; School of Medicine, Nankai University, Tianjin, China.
Neural Regen Res. 2016 Oct;11(10):1644-1652. doi: 10.4103/1673-5374.193245.
Polypyrrole (PPy) is a biocompatible polymer with good conductivity. Studies combining PPy with electrospinning have been reported; however, the associated decrease in PPy conductivity has not yet been resolved. We embedded PPy into poly(lactic acid) (PLA) nanofibers electrospinning and fabricated a PLA/PPy nanofibrous scaffold containing 15% PPy with sustained conductivity and aligned topography. There was good biocompatibility between the scaffold and human umbilical cord mesenchymal stem cells as well as Schwann cells. Additionally, the direction of cell elongation on the scaffold was parallel to the direction of fibers. Our findings suggest that the aligned PLA/PPy nanofibrous scaffold is a promising biomaterial for peripheral nerve regeneration.
聚吡咯（PPy）是一种具有良好导电性的生物相容性聚合物。已有将PPy与静电纺丝相结合的研究报道；然而，与之相关的PPy导电性下降问题尚未得到解决。我们将PPy嵌入聚乳酸（PLA）纳米纤维静电纺丝中，制备了一种含有15%PPy的PLA/PPy纳米纤维支架，该支架具有持续的导电性和排列整齐的形貌。该支架与人脐带间充质干细胞以及雪旺细胞之间具有良好的生物相容性。此外，细胞在支架上的伸长方向与纤维方向平行。我们的研究结果表明，排列整齐的PLA/PPy纳米纤维支架是一种用于周围神经再生的有前景的生物材料。
