脑室内注射降钙素基因相关肽抗血清对大鼠主动回避行为的调节作用

Modulation of active avoidance behavior of rats by ICV administration of CGRP antiserum.

作者信息

Kovcs A, Telegdy G

机构信息

Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.

出版信息

Peptides. 1994;15(5):893-5. doi: 10.1016/0196-9781(94)90047-7.

DOI:10.1016/0196-9781(94)90047-7

PMID:7984510

Abstract

The effects of ICV administration of CGRP antiserum on active avoidance behavior were studied in rats. CGRP antiserum dilutions of 1:5, 1:10, 1:20, and 1:40 facilitated the extinction of active avoidance responses in a platform-jumping situation in the 3- and 6-h tests. In the 24-h test, only the CGRP antiserum dilution of 1:5 was effective. The present findings suggest that the endogenous CGRP of the brain may be a physiological modulator in extinction processes of active avoidance behavior.

摘要

在大鼠中研究了脑室内注射降钙素基因相关肽（CGRP）抗血清对主动回避行为的影响。在3小时和6小时的试验中，1:5、1:10、1:20和1:40的CGRP抗血清稀释液在平台跳跃情境中促进了主动回避反应的消退。在24小时的试验中，只有1:5的CGRP抗血清稀释液有效。目前的研究结果表明，脑内源性CGRP可能是主动回避行为消退过程中的一种生理调节因子。