Kovcs A, Telegdy G
Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Peptides. 1994;15(5):893-5. doi: 10.1016/0196-9781(94)90047-7.
The effects of ICV administration of CGRP antiserum on active avoidance behavior were studied in rats. CGRP antiserum dilutions of 1:5, 1:10, 1:20, and 1:40 facilitated the extinction of active avoidance responses in a platform-jumping situation in the 3- and 6-h tests. In the 24-h test, only the CGRP antiserum dilution of 1:5 was effective. The present findings suggest that the endogenous CGRP of the brain may be a physiological modulator in extinction processes of active avoidance behavior.
在大鼠中研究了脑室内注射降钙素基因相关肽（CGRP）抗血清对主动回避行为的影响。在3小时和6小时的试验中，1:5、1:10、1:20和1:40的CGRP抗血清稀释液在平台跳跃情境中促进了主动回避反应的消退。在24小时的试验中，只有1:5的CGRP抗血清稀释液有效。目前的研究结果表明，脑内源性CGRP可能是主动回避行为消退过程中的一种生理调节因子。
